| 基质金属蛋白酶-13的测定在骨关节炎中作用的研究进展 |
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投稿时间：2013-12-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 陈文晓 |
CHEN Wen-xiao |
浙江中医药大学, 浙江 杭州 310053 |
Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China |
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| 单方军 |
SHAN Fang-jun |
浙江中医药大学, 浙江 杭州 310053 |
Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China |
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| 金红婷 |
JIN Hong-ting |
浙江中医药大学, 浙江 杭州 310053 |
Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China |
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| 王萍儿 |
WANG Ping-er |
浙江中医药大学, 浙江 杭州 310053 |
Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China |
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| 肖鲁伟 |
XIAO Lu-wei |
浙江中医药大学, 浙江 杭州 310053 |
Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China |
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| 童培建 |
TONG Pei-jian |
浙江中医药大学, 浙江 杭州 310053
浙江省中医骨伤研究所, 浙江 杭州 310053 |
Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China |
tongpeijian@163.com |
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| 期刊信息：《中国骨伤》2014年，第27卷，第7期，第617-620页 |
| DOI：10.3969/j.issn.1003-0034.2014.07.020 |
| 基金项目:2013浙江省科技厅第二批重大科技专项重大社会发展项目（编号：2012c13017-2） |
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| 中文摘要:骨关节炎是在复杂的生物学和力学因素共同作用下，软骨细胞、细胞外基质、软骨下骨三者合成与降解失衡的一种慢性、进行性疾病，其病因和病理机制目前尚未完全明确，但基质金属蛋白酶-13（MMP-13）对Ⅱ型胶原所组成三螺旋结构的降解和破坏被认为是OA发生发展的关键环节，MMP-13抑制剂的研究将会为OA的治疗提供新的思路和方法。 |
| 【关键词】基质金属蛋白酶-13 骨关节炎 软骨，关节 胶原 综述文献 |
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| Research on application of determination of MMP-13 in osteoarthritis |
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| ABSTRACT Osteoarthritis (OA) is a complex chronic progressive disease attacked by biological and mechanical factors and a result from the anabolic and catabolic imbalance in chondrocyte,subchondral bone and extracellular matrix(ECM). Etiology and pathological of OA are not yet entirely clear. The degradation and destruction of collagen Ⅱ caused by matrix metalloproteinase-13(MMP-13) is considered the core factor in the occurrence and development of OA. The research of MMP-13 inhibitor provide ideas and methods for the treatment of OA. In this article,the role and determination of MMP-13 in OA and the development prospect of MMP-13 inhibitor in the treatment of OA research progress were reviewed. |
| KEY WORDS Matrix metalloproteinase-13 Osteoarthritis Cartilage,articular Collagen Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陈文晓,单方军,金红婷,王萍儿,肖鲁伟,童培建.基质金属蛋白酶-13的测定在骨关节炎中作用的研究进展[J].中国骨伤,2014,27(7):617~620 |
| 英文格式: | CHEN Wen-xiao,SHAN Fang-jun,JIN Hong-ting,WANG Ping-er,XIAO Lu-wei,TONG Pei-jian.Research on application of determination of MMP-13 in osteoarthritis[J].zhongguo gu shang / China J Orthop Trauma ,2014,27(7):617~620 |
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