| 微弧氧化ZK60镁合金生物安全性和降解性的体内实验研究 |
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投稿时间：2013-01-12
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| 作者 | Author | 单位 | Address | E-Mail |
| 殷毅 |
YIN Yi |
解放军总医院骨科, 北京 100853 |
Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China |
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| 张强 |
ZHANG Qiang |
解放军总医院骨科, 北京 100853 |
Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China |
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| 齐峥嵘 |
QI Zheng-rong |
解放军总医院骨科, 北京 100853 |
Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China |
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| 王岩 |
WANG Yan |
解放军总医院骨科, 北京 100853 |
Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China |
yanwang301@yahoo.com |
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| 期刊信息：《中国骨伤》2013年，第26卷，第5期，第423-428页 |
| DOI：10.3969/j.issn.1003-0034.2013.05.018 |
| 基金项目:国家高技术研究发展计划(863)资助项目(编号:2011AA030101) |
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中文摘要:
目的: 研究经微弧氧化处理的ZK60镁合金(MAO-ZK60)植入动物体内后的组织毒性和降解性来探讨其作为骨科植入材料的可能。
方法: 将18只SD大鼠随机均分为3组(A、B、C组):A组为实验组, 在大鼠股骨髁内植入经微弧氧化处理的ZK60镁合金(MAO-ZK60)棒;B组植入表面未经处理的ZK60镁合金(ZK60)棒;C组植入医用高分子左旋聚乳酸(PLLA)棒, B、C组分别为对照组。观察并比较不同组之间的血生化指标的动态变化。12周后处死实验动物后取材, 病理切片观察肝、肾组织形态变化, 判断有无肝肾毒性。micro-CT检查观察镁合金在大鼠体内降解情况及植入体-骨组织界面, 并用GEHC MicroView软件计算镁合金植入体体积的变化。
结果: 各组随时间变化生化指标无显着变化, 差异无统计学意义。各组肝、肾组织病理组织切片均未见异常。micro-CT显示A组4周时骨-植入体界面有空隙开始形成, 8周时空隙开始逐渐减小, 至12周时空隙继续减小并且植入物与骨质结合较好。A组的体积随时间的改变小于B组(P<0.05)。
结论: 经微弧氧化处理的ZK60镁合金在动物体内表现出良好的完全性, 其耐腐蚀性较未经处理的ZK60镁合金有所提高。 |
| 【关键词】镁化合物 骨生成 植入物, 实验性 大鼠 |
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| In vivo experimental study on MAO-ZK60 magnesium alloy bio-safety and degradation |
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ABSTRACT
Objective: To investigate the tissue toxicity and degradation of ZK60 magnesium alloy with micro-arc oxidation coatings(MAO-ZK60),in order to discuss the possibility of its potential application for orthopedic implantation.
Methods: Eighteen Sprague-Dawley rats were randomized equally to three groups of A,B,C. MAO-ZK60 sticks were implanted in the femoral condyles of rats in group A(experimental group). Sticks of ZK60 magnesium alloy without any surface treatment (ZK60) were implanted in the femoral condyles of rats in group B (control group). The poly L-lactic acid (PLLA) sticks were implanted in the femoral condyles of rats in group C (control group). The changes of blood bio-chemical indexes of different groups were observed and compared. All the rats were sacrificed at 12 weeks and histological observation of liver and kidney were carried out to evaluate the hepatic and renal toxicity. Micro-CT was used to evaluate the degradation of the implants and to observe the bone-implant interface. GEHC MicroView software was operated to calculate the volume variation of magnesium alloy.
Results: There was no apparent biochemical index change with time in each group,and there was no significant change among each group. No significant pathology change of liver and kidney was detected among three groups. By using a micro-CT,a gap was found on the bone-implant interface at 4 weeks after implantation in group A,which decreased gradually at 8 weeks after implantation and continued to decrease at 12 weeks after implantation. A good combination between bone and implant formed at 12 weeks after implantation. Group A has less change of volume with time than group B (P<0.05).
Conclusion: ZK60 magnesium alloy with micro-arc oxidation coatings is safe in vivo. It has higher corrosion resistance than ZK60 magnesium alloy without any surface treatment. |
| KEY WORDS Magnesium compounds Osteogenesis Implants,experimental Rats |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 殷毅,张强,齐峥嵘,王岩.微弧氧化ZK60镁合金生物安全性和降解性的体内实验研究[J].中国骨伤,2013,26(5):423~428 |
| 英文格式: | YIN Yi,ZHANG Qiang,QI Zheng-rong,WANG Yan.In vivo experimental study on MAO-ZK60 magnesium alloy bio-safety and degradation[J].zhongguo gu shang / China J Orthop Trauma ,2013,26(5):423~428 |
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