| 幽门螺旋杆菌感染与骨质疏松症的研究进展 |
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投稿时间：2011-05-05
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| 期刊信息：《中国骨伤》2011年，第24卷，第11期，第966-968页 |
| DOI：10.3969/j.issn.1003-0034.2011.11.027 |
| 基金项目: |
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| 中文摘要:幽门螺旋杆菌是一种易侵犯胃黏膜的传染性病原体，感染机体后，可刺激体内肿瘤坏死因子及白细胞介素等细胞因子的释放。这些细胞因子调控骨的吸收或转化，促进破骨细胞形成及骨吸收，从而导致局部或全身的骨质疏松。幽门螺旋杆菌感染后可能引起血清雌激素、维生素B12等的降低，后两者可能是影响骨质疏松发病的重要因素。同时，幽门螺旋杆菌感染与胃炎、消化道溃疡、胃癌的发病密切相关，而这些疾病及治疗可能与骨质疏松相关，质子泵抑制剂(proton pump inhibitor,PPI)的应用可能会影响肠道钙的吸收，降低血钙以及增加骨折风险，胃切除术可能导致骨代谢障碍。 |
| 【关键词】螺杆菌，幽门 骨质疏松 质子泵 钙通道阻滞药 胃切除术 骨密度 细胞因子类 |
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| Progress of research between helicobacter pylori infection and osteoporosis |
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| ABSTRACT Helicobacter pylori(HP) is an infectious pathogen which can easily infringe gastric mucosa. If the body is infected by HP, it can release cytokines, such as TNF-α, IL-1 and IL-6. These cytokines can regulate the absorption and transformation of bone, promote the formation of osteoclast, and then cause localized or systemic osteoporosis. HP infection may decrease the level of estrogen and vitamin B12, which is considered as a risk factor for osteoporosis. Helicobacter pylori infection is related with the occurrence of gastritis, peptic ulcer and gastric malignancies, and these diseases and treatments are associated with osteoporosis. Meanwhile the application of proton pump inhibitor(PPI) can influence absorption of calcium, decrease the level of serum calcium and increase the risk of fracture. Gastrostomy may cause bone metabolism disorders. |
| KEY WORDS Helicobacter pylori Osteoporosis Proton pumps Calcium channel blockers Gastrectomy Bone density Cytokines |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 徐中海,张骏,杨迪,章建华.幽门螺旋杆菌感染与骨质疏松症的研究进展[J].中国骨伤,2011,24(11):966~968 |
| 英文格式: | XU Zhong-hai,ZHANG Jun,YANG Di,ZHANG Jian-hua.Progress of research between helicobacter pylori infection and osteoporosis[J].zhongguo gu shang / China J Orthop Trauma ,2011,24(11):966~968 |
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