| 温阳补肾中药促进骨髓基质细胞分化的实验研究进展 |
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投稿时间：2010-09-26
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| 期刊信息：《中国骨伤》2011年，第24卷，第4期，第352-356页 |
| DOI：10.3969/j.issn.1003-0034.2011.04.025 |
| 基金项目:国家自然科学基金项目(编号：30973763);博士学科点专项基金：(编号：20093519110001) |
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| 中文摘要:骨髓基质细胞(BMSCs)是存在于骨髓中的一种干细胞, 具有自我更新、高度增殖能力和多向分化的潜能, 故在细胞替代治疗、基因治疗、组织工程等方面具有良好的应用前景。但由于骨髓中BMSCs含量极少, 必须通过体外培养扩增、诱导分化才能满足临床需求。近年来, 研究发现中药诱导BMSCs增殖、分化是非常有潜力的一条途径, 基于“肾主骨生髓”和“肾藏精、精生髓”的中医理论, 中医学者们就温阳补肾中药在促进BMSCs增殖和分化方面进行了探索, 发现该类药物具有促进BMSCs增殖及向成骨、软骨、神经细胞分化的作用。本文就此方面的研究进行阐述和介绍。 |
| 【关键词】温阳补肾 中草药： 干细胞，骨髓 综述文献 |
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| Experimental research progress of warming yang and reinforcing kidney(温阳补肾) of Chinese medicine to promote the differentiation of bone marrow stromal cells |
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| ABSTRACT Bone marrow stromal cells(BMSCs), a kind of stem cells residing in bone marrow, have self-renewal, high proliferative capacity and the potential of multilineage differentiation. It has a good prospect in application of the cell replacement therapy, the gene therapy and the tissue engineering and so on. As the content of BMSCs is extremely low in bone marrow, BMSCs must be amplified in vitro and induced to differentiation to meet the clinical needs. Researches of the recent years suggest there is a very promising way that Chinese medicine could induce BMSCs proliferation, differentiation. Based on the Chinese medicine theory, “the kidney generating marrow and dominating bone”and “kidney storing essence, essence and marrow”, the TCM scholars have done some researches to explore the function of warming yang and reinforcing kidney(温阳补肾) of Chinese medicine to promote bone marrow stromal cells and found that these drugs can promote the BMSCs to proliferate and to differentiate into osteogenic, cartilage and nerve cells. This article elaborates and presents the researches on this aspect. |
| KEY WORDS Warming yang and reinforcing kidney (温阳补肾) Drugs, Chinese herbal Stem cell, myeloid Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陈卫衡,王和鸣.温阳补肾中药促进骨髓基质细胞分化的实验研究进展[J].中国骨伤,2011,24(4):352~356 |
| 英文格式: | CHEN Wei-heng,WANG He-ming.Experimental research progress of warming yang and reinforcing kidney(温阳补肾) of Chinese medicine to promote the differentiation of bone marrow stromal cells[J].zhongguo gu shang / China J Orthop Trauma ,2011,24(4):352~356 |
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