| 脑外伤对骨折愈合影响的实验研究 |
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投稿时间：2005-04-28
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| 作者 | Author | 单位 | Address | E-Mail |
| 黄浩 |
HUANG Hao |
金坛市中医院,,江苏金坛213200 |
The TCM Hospital of Jintan,Jintan 213200,Jiangsu,China |
huanghao123700@sohu.com |
| 恽时峰 |
YUN Shi-feng |
中国人民解放军南京军区南京总医院实验动物中心 |
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| 王跃 |
WANG Yue |
金坛市中医院,,江苏金坛213200 |
The TCM Hospital of Jintan,Jintan 213200,Jiangsu,China |
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| 高萍 |
GAO Ping |
金坛市中医院,,江苏金坛213200 |
The TCM Hospital of Jintan,Jintan 213200,Jiangsu,China |
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| 李新华 |
LI Xin-hua |
金坛市中医院,,江苏金坛213200 |
The TCM Hospital of Jintan,Jintan 213200,Jiangsu,China |
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| 杭明富 |
HANG Ming-fu |
金坛市中医院,,江苏金坛213200 |
The TCM Hospital of Jintan,Jintan 213200,Jiangsu,China |
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| 马勇 |
MA Yong |
,南京中医药大学骨伤教研室 |
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| 马德忠 |
MA De-zhong |
金坛市中医院,,江苏金坛213200 |
The TCM Hospital of Jintan,Jintan 213200,Jiangsu,China |
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| 期刊信息：《中国骨伤》2006年，第19卷，第3期，第166-167页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:江苏省金坛市科学技术局资助项目(编号:坛科字(2001)第26号-29) |
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中文摘要:
目的:探讨脑外伤对骨折愈合的影响及作用机制。
方法:用新西兰大耳白家兔65只,分别制成单纯股骨干骨折、脑外伤合并股骨干骨折及脑外伤1周后合并股骨干骨折模型。分别于术后第1、2、3、4周各处死5只家兔,摄骨折处X线片,观察骨折愈合情况。进行病理、组织学检查,检测转化生长因子-α。
结果:实验表明,脑外伤合并股骨干骨折的家兔骨折愈合速度快,而无脑外伤的单纯股骨干骨折家兔,其骨折愈合速度较慢。
结论:脑外伤后家兔骨折愈合的速度加快,这可能与脑外伤后家兔体内生长因子特别是转化生长因子-α水平升高有关。 |
| 【关键词】脑损伤,创伤性 骨折愈合 股骨骨折 转化生长因子α |
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| Experimental study on the effects of cerebral trauma on fracture healing |
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ABSTRACT
Objective:To explore the effects of cerebral trauma on fracture healing and to study its mechanism.
Methods:Sixty-five New Zealand rabbits were sacrificed to produce models of femoral shaft fracture,femoral shaft fracture accompanied with cerebral trauma,and femoral shaft fracture at 1st week after cerebral trauma respectively.Every five rabbits were killed at 1st,2nd,3rd and 4th weeks after operation.X-ray examinations were performed to observe fracture healing.Pathologic and histological examinations were also performed and the contents of transforming growth factor-α in serum were detected.
Results:The fracture healing in femoral shaft fracture accompanied with cerebral trauma models was rapid,while in simple femoral shaft fracture models was slow.
Conclusion:The union of fracture is accelerated by the factor of cerebral trauma,which is perhaps related to increase of TNF-α after cerebral trauma of rabbits. |
| KEY WORDS Brain injuries,traumatic Fracture healing Femoral fractures Transforming growth factor alpha |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 黄浩,恽时峰,王跃,高萍,李新华,杭明富,马勇,马德忠.脑外伤对骨折愈合影响的实验研究[J].中国骨伤,2006,19(3):166~167 |
| 英文格式: | HUANG Hao,YUN Shi-feng,WANG Yue,GAO Ping,LI Xin-hua,HANG Ming-fu,MA Yong,MA De-zhong.Experimental study on the effects of cerebral trauma on fracture healing[J].zhongguo gu shang / China J Orthop Trauma ,2006,19(3):166~167 |
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