| 健骨颗粒对去卵巢骨质疏松模型鼠钙调节激素的影响 |
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投稿时间：2004-04-30
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| 作者 | Author | 单位 | Address | E-Mail |
| 林燕萍 |
LIN Yan-ping |
福建中医学院骨伤系,福建福州350003 |
Department of Orthopaedics &
Traumatology,Fujian College of TCM,Fujian Fuzhou,350003,China |
ypling @sina. com. cn |
| 周瑞祥 |
ZHOU Rui-xiang |
福建医科大学基础医学院 |
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| 冯尔宥 |
FENG Er-you |
福建中医学院骨伤系,福建福州350003 |
Department of Orthopaedics &
Traumatology,Fujian College of TCM,Fujian Fuzhou,350003,China |
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| 黄美雅 |
HUANG Mei-ya |
福建中医学院骨伤系,福建福州350003 |
Department of Orthopaedics &
Traumatology,Fujian College of TCM,Fujian Fuzhou,350003,China |
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| 期刊信息：《中国骨伤》2005年，第18卷，第1期，第22-24页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:福建省自然科学基金重大项目(C9830001);福建省教育厅科技三项费用项目(K02083) |
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中文摘要:
目的:探讨健骨颗粒对骨质疏松模型鼠三种主要钙调节激素水平的影响。
方法:切除雌性大鼠卵巢建立绝经后骨质疏松症病理模型,分别喂服健骨颗粒、骨松宝和生理盐水,用放射免疫测定法检测血清甲状旁腺激素(PTH)、1,25二羟维生素D3[1,25(OH)2D3]、降钙素(CT)和雌二醇(E2)水平。
结果:卵巢切除后随着血清E2水平的下降,1,25(OH)2D3、CT含量明显下降(P<001或P<005),而PTH却显著上升(P<001)。用药后健骨颗粒组血清1,25(OH)2D3、CT水平显著回升(P<001或P<005),而PTH浓度出现下降(P<001)。E2与CT、1,25(OH)2D3呈正相关,而与PTH呈负相关;PTH与1,25(OH)2D3、CT呈负相关,1,25(OH)2D3与CT呈正相关。
结论:健骨颗粒能通过协调骨质疏松模型鼠血清PTH、1,25(OH)2D3、CT三种钙调节激素浓度,改善因E2下降对骨代谢产生的副作用,这可能是健骨颗粒有效防治骨质疏松症的主要作用机制之一。 |
| 【关键词】骨质疏松 绝经后 激素 放射免疫测定 动物 实验 |
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| Effect of Jiangu Granula on Ca2+ regulating hormone of ovariectomized rats |
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ABSTRACT
Objective:To investigate the effect of Jiangu Granula（JGG） on the concentration of three Ca2+ regulate hormone of osteoporosis（OP） rats.
Methods:SD rats with ovariectomy were randomly divided into three groups:Normal saline group,Gusongbao group,JGG group.The serum concentrations of PTH,CT,1,25-（OH）2D3,E2 were measured by radioimmunoassay（RIA）.
Results::The levels of 1,25-（OH）2D3 and CT in serum were decreased（P<0.01 or P<0.05）at 12 weeks after operation,but PTH were increased.The levels of 1,25-（OH）2D3 and CT in the JGG group were increased,but PTH were decreased compared with normal saline group.We found that there was a negative correlation between E2 and PTH,PTH and 1,25-（OH）2D3,CT,but it has a positive correlation between E2 and CT,1,25-（OH）2D3,so as to 1,25-（OH）2D3 and CT.
Conclusion:JGG can coordinate comprehensively the concentration of PTH,1,25-（OH）2D3,CT ,and reduce side effects to bone metabolism caused by the decline of E2 level.Maybe it is the one of main active mechanisms that JGG can cure or prevent effectively from the postmenopausal osteoporosis. |
| KEY WORDS Osteoporosis,postmenopausal Hormone Radioimmunoassay Animals,laboratory |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 林燕萍,周瑞祥,冯尔宥,黄美雅.健骨颗粒对去卵巢骨质疏松模型鼠钙调节激素的影响[J].中国骨伤,2005,18(1):22~24 |
| 英文格式: | LIN Yan-ping,ZHOU Rui-xiang,FENG Er-you,HUANG Mei-ya.Effect of Jiangu Granula on Ca2+ regulating hormone of ovariectomized rats[J].zhongguo gu shang / China J Orthop Trauma ,2005,18(1):22~24 |
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