| 健骨冲剂对去卵巢大鼠股骨及腰椎的生物力学作用 |
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投稿时间：2000-06-08 修订日期：2000-12-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 王晓达 |
WANG Xiao da |
上海第二医科大学附属瑞金医院,上海200025 |
Ruijin Hospital affiliated to Shanghai 2nd Medical University Shanghai,200025 |
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| 张风华 |
ZHANG Feng hua |
上海第二医科大学附属瑞金医院,上海200025 |
Ruijin Hospital affiliated to Shanghai 2nd Medical University Shanghai,200025 |
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| 符诗聪 |
FU Shi cong |
上海第二医科大学附属瑞金医院,上海200025 |
Ruijin Hospital affiliated to Shanghai 2nd Medical University Shanghai,200025 |
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| 史炜镔 |
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上海第二医科大学附属瑞金医院,上海200025 |
Ruijin Hospital affiliated to Shanghai 2nd Medical University Shanghai,200025 |
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| 杜宁 |
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上海第二医科大学附属瑞金医院,上海200025 |
Ruijin Hospital affiliated to Shanghai 2nd Medical University Shanghai,200025 |
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| 李国衡 |
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上海第二医科大学附属瑞金医院,上海200025 |
Ruijin Hospital affiliated to Shanghai 2nd Medical University Shanghai,200025 |
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| 期刊信息：《中国骨伤》2001年，第14卷，第10期，第601-603页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:上海市科委基金资助项目(合同编号:974119035) |
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中文摘要:
目的：研究不同剂量健骨冲剂预防去卵巢1月后SD大鼠生物力学特性降低的疗效。
方法：77只6月龄雌性SD大鼠随机分为7组:假手术(Sham)组、卵巢切除(OVX)组、尼尔雌醇(E)组、仙灵骨葆(X)组、健骨冲剂低剂量(JL)组、健骨冲剂高剂量(JH)组、健骨冲剂中剂量(JM)组,每组11只；除Sham组外,其余各组行卵巢摘除术诱导绝经后骨质疏松症模型,术后除OVX组各治疗组分别给药,1月后测定生物力学指标。
结果：JH组股骨抗弯程度显着高于OVX组,股骨中段直径显着小于后者；JM组腰椎抗压强度显着高于OVX组；3种剂量组股骨弹性模量和椎体直径显着高于E组,腰椎抗压强度均显着低于后者。
结论：低、中剂量健骨冲剂短期应用能够预防OVX术大鼠骨折危险性增加的趋势。 |
| 【关键词】补肾药 骨质疏松 绝经后 生物力学 |
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| Biomechanical effects of Jiangu Chongji(a TCM decoction) on femur and lumbar vertebrae of ovariectomy female rats |
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ABSTRACT
Objective:To study the biomechanical effect with different dosage of Jiangu Chongji(JC) on ovariectomy SD rats
Methods: 77 female SD rats at 6 months were randomly divided into 7 groups of 11 each:Sham group,OVX group,E group,X group,JL group,JH group,JM group.All the animals had ovariectomy except those in the Sham group and treated 1 month seperatly except OVX group.The biomechanical index of femur and lumbar vertebrae of ovariectomy female rats were measured after 1 month.
Results:The mechanical strength and diameter of the femur in low dose group were significantly higher than that of OVX group and diameter of the femur smaller than latter;the lumbar vertebrae compressive strength in middle dose group were higher,and the modulus of elasticity of the femur and diameter of the lumbar vertebrae in the 3 JC groups were signficantly higher than that of the estrogen group and the lumbar vertebrae compressive strength were lower than the latter.
Conclusion:JC appears to be able to prevent increasing risk of fracture in ovariectomized rats. |
| KEY WORDS Kidney reinforcing drugs Osteoporosis postmenopausal Biomechanics |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 王晓达,张风华,符诗聪,史炜镔,杜宁,李国衡.健骨冲剂对去卵巢大鼠股骨及腰椎的生物力学作用[J].中国骨伤,2001,14(10):601~603 |
| 英文格式: | WANG Xiao da,ZHANG Feng hua,FU Shi cong.Biomechanical effects of Jiangu Chongji(a TCM decoction) on femur and lumbar vertebrae of ovariectomy female rats[J].zhongguo gu shang / China J Orthop Trauma ,2001,14(10):601~603 |
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