| 肝细胞生长因子对膝关节软骨影响的临床意义 |
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投稿时间：1999-11-17
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| 期刊信息：《中国骨伤》2000年，第13卷，第7期，第401-403页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的:研究前列腺素E2(PGE2)参与关节软骨退变的进程机理,以及肝细胞生长因子(HGF)对膝关节软骨损伤修复的作用机理。
方法:对符合临床诊断标准的30个膝关节,分别给予膝关节腔注射肝细胞生长因子,每天1次,每次2ml,观察PGE2、尿中Ⅰ型胶原(crosslaps)、碱性磷酸酶(AKP)以及临床症状的改善程度,并做了给药6周后与给药前的对比研究。
结果:给药6周后crosslaps和PGE2与给药前比较均明显降低(P<0.01,P<0.001).给药6周后临床症状均有不同程度的改善。
结论:PGE2参与了软骨损伤的某些阶段,肝细胞生长因子对膝关节软骨的修复有促进作用。 |
| 【关键词】软骨 关节 膝关节 前列腺素E类 |
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| Clinical effect of hepatocyte growth factor on articular cartilage of the knee |
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ABSTRACT
Objective:To explore the mechanism of prostaglandins E2(PGE2) affecting cartilage degeneration stage and the effect of hepatocyte growth factor(HGF) on the repair of injured articular cartilage of the knee.
Methods:HGF(2 ml,once daily)were injected into 30 knee joints which met to clinical diagnostic standard of osteoarthritis.The PGE2,crosslaps,AKP and the improvement of clinical symptom were investigated.
Results:After 6 weeks,the contents of PGE2 and crosslaps decreased notably compared with that of before the treatment (P<0 01,P<0 001),meanwhile the clinical symptoms were also improved to different extents.
Conclusion:PGE2 had involvements in certain stages of articular cartilage damage.HGF had a promotion effect on the repair process of cartilage. |
| KEY WORDS Cartilage articular Knee joint Prostaglandins E |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陈百成,张静,葛莉,苏莉.肝细胞生长因子对膝关节软骨影响的临床意义[J].中国骨伤,2000,13(7):401~403 |
| 英文格式: | CHEN Bai cheng,ZHANG Jing,GE Li.Clinical effect of hepatocyte growth factor on articular cartilage of the knee[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(7):401~403 |
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