| 组织工程技术在肌腱损伤修复中的研究进展 |
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Received:August 13, 2024
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| 作者 | Author | 单位 | Unit | E-Mail |
| 王彦军 |
WANG Yan-jun |
海军军医大学第一附属医院急诊科, 上海 200433 |
Department of Emergency, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China |
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| 孔令同 |
KONG Ling-tong |
海军军医大学第一附属医院创伤骨科, 上海 200433 |
Department of Orthopaedics, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China |
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| 许硕贵 |
XU Shuo-gui |
海军军医大学第一附属医院创伤骨科, 上海 200433 |
Department of Orthopaedics, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China |
Shuogui_xu@smmu.edu.cn |
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| 期刊信息：《中国骨伤》2024年37卷，第11期，第1126-1131页 |
| DOI：10.12200/j.issn.1003-0034.20240545 |
| 基金项目:国家重点研发计划(编号:2023YFC3107200);国家自然科学基金(编号:82302718) |
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| 肌腱损伤是临床常见病,传统修复技术鲜能完全恢复肌腱原始结构与功能,如何加速并优化损伤肌腱的愈合,增加新生肌腱强度及防止肌腱粘连一直是临床上面临的严峻挑战,肌腱组织工程整合了材料工程学、细胞生物学和分子生物学,涉及使用多种因素的组合来产生功能性结构,逐渐成为下一个有前途的修复技术。如何发挥这些元素最大的组织再生能力是重要的研究课题,未来的探索应集中在发现细胞、生物信号和支架的最佳组合上,从而产生模仿天然无损伤肌腱的再生组织。本文将从肌腱组织支架的构建、种子细胞的选择、愈合相关生物信号调控策略、总结与展望等几个方面进行综述,以期深化对组织工程技术在肌腱损伤修复领域的理解,并为提出新的组织工程应用方案提供思考。 |
| [关键词]:肌腱 损伤与修复 组织工程支架 种子细胞 生物信号 |
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| Research progress on the repair of tendon injuries with Tissue Engineering Technology |
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| Abstract:Tendon injuries are frequently encountered in clinical practice,and traditional repair methods rarely achieve complete restoration of the tendon's original structure and functionality. The challenges of accelerating and optimizing the healing of injured tendons,enhancing the strength of the regenerated tendon,and preventing adhesion remain significant in clinical settings. Tendon tissue engineering,which combines material science,cell biology,and molecular biology,involves the synergistic application of multiple factors to create functional constructs and has become an emerging technique with promise for repair. The maximization of the regenerative potential of these elements is a critical research question. Future research should concentrate on discovering the optimal combinations of cells,biosignals,and scaffolds to produce tissue that emulates the characteristics of an undamaged,natural tendon. This review will cover various aspects,including the fabrication of tendon tissue scaffolds,the selection of seed cells,strategies for the modulation of healing-related biosignals,and provide a summary with prospective insights,aiming to enhance the comprehension of tissue engineering techniques in tendon injury repair and to inspire innovative applications in this domain. |
| KEYWORDS:Tendon Injury and repair Tissue engineering scaffold Seed cells Biosignals |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 王彦军,孔令同,许硕贵.组织工程技术在肌腱损伤修复中的研究进展[J].中国骨伤,2024,37(11):1126~1131 |
| 英文格式: | WANG Yan-jun,KONG Ling-tong,XU Shuo-gui.Research progress on the repair of tendon injuries with Tissue Engineering Technology[J].zhongguo gu shang / China J Orthop Trauma ,2024,37(11):1126~1131 |
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