| 特应性疾病与骨关节炎的因果关系：一项孟德尔随机化研究 |
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Received:November 10, 2023
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| 作者 | Author | 单位 | Unit | E-Mail |
| 张明琛 |
ZHANG Ming-chen |
北京中医药大学, 北京 100029 |
Beijing University of Chinese Medicine, Beijing 100029, China |
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| 林安 |
LIN An |
北京中医药大学, 北京 100029 |
Beijing University of Chinese Medicine, Beijing 100029, China |
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| 桑志成 |
SANG Zhi-cheng |
中国中医科学院望京医院, 北京 100102 |
Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China |
sangzhch@126.com |
| 葛琳 |
GE Lin |
北京中医药大学, 北京 100029
中国中医科学院广安门医院, 北京 100053 |
Beijing University of Chinese Medicine, Beijing 100029, China
Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing 100053, China |
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| 期刊信息：《中国骨伤》2024年37卷，第9期，第904-909页 |
| DOI：10.12200/j.issn.1003-0034.20230868 |
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目的: 探讨采用孟德尔随机化(Mendelian randomization,MR)研究探讨特应性疾病(哮喘和特应性皮炎)与骨关节炎(osteoarthritis,OA)之间的因果关系。
方法: 选择哮喘和特应性皮炎作为工具变量,通过IEU数据库进行检索,选择最新及病例数、单核苷酸多态性(single nucleotide polymorphism,SNP)数量较多的数据,使用R语言对数据进行收集处理,采用逆方差加权(inverse-varianceweighted,IVW)方法作为主要的MR评估方法,根据全基因组关联研究(genome-wide association studies,GWAS)中膝及髋关节汇总数据进行单一线性回归估计因果关系。绘制森林图对结果进行可视化处理,散点图、漏斗图等进行基因多效性分析及敏感性分析。同时选择哮喘、特应性皮炎、身体质量指数(body mass index,BMI)、骨质疏松症与OA进行多变量MR分析排除GWAS数据中水平多效性对结果的影响。
结果: MR-IVW结果显示,哮喘与OA存在因果关系[OR=1.41,95%CI(1.07,1.85),P=0.02],使用多变量孟德尔随机化法(multivariate Mendelian randomization,MVMR)对BMI、骨质疏松症进行调整后,结果发现哮喘对OA的因果效应保持不变[OR=1.57,95%CI(1.03,2.39),P=0.03]。特应性皮炎与OA的两样本MR结果为[OR=1.01,95%CI(0.97,1.04),P=0.76],MVMR结果为[OR=1.02,95%CI(0.99,1.05),P=0.25],均提示二者无明确的因果关系。讨论:哮喘会增加OA的发病风险,特应性皮炎与OA的发病无明显关系,特应性疾病与OA的关系仍需讨论。 |
| [关键词]:特应性疾病 骨关节炎 哮喘 特应性皮炎 孟德尔随机化 |
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| Causality between atopic diseases and osteoarthritis:a Mendelian randomization study |
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Abstract:
Objective To explore causal relationship between atopic diseases (asthma and atopic dermatitis) and osteoarthritis (OA) by using mendelian randomization(MR).
Methods Asthma and atopic dermatitis as instrumental variables were selected,searched them through IEU database,and selected the latest data with a large number of cases and single nucleotide polymorphism (SNP). Data were collected and processed using R language,inverse varianceweighted (IVW) method was adopted as main MR Evaluation method. Single linear regression was performed to estimate causality based on pooled knee and hip data from genome-wide association studies (GWAS). The forest map was drawn to visualize the results,and gene pleiotropy and sensitivity were analyzed by scatter plot and funnel plot. At the same time,asthma,atopic dermatitis,body mass index (BMI),osteoporosis and OA were selected for multivariate MR Analysis to exclude the effect of horizontal pleiotropy on the results in GWAS data.
Results Analysis of MR-IVW results showed asthma was positively correlated with causal effect of OA[OR=1.41,95%CI(1.07,1.85),P=0.02],multivariate Mendelian randomization (MVMR) adjusted for BMI and osteoporosis and a direct causal effect on OA was observed[OR=1.57,95%CI(1.03,2.39),P=0.03)]. MR Results of two samples of atopic dermatitis and OA were[OR=1.01,95%CI(0.97,1.04),P=0.76],and MVMR results were[OR=1.02,95%CI(0.99,1.05),P=0.25],indicating no clear causal relationship between two samples.
Conclusion Asthma could increase risk of OA,atopic dermatitis has no obvious relationship with OA,and the relationship between atopic diseases and OA still needs to be discussed. |
| KEYWORDS:Atopic disease Osteoarthritis Asthma Atopic dermatitis Mendelian randomization |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 张明琛,林安,桑志成,葛琳.特应性疾病与骨关节炎的因果关系：一项孟德尔随机化研究[J].中国骨伤,2024,37(9):904~909 |
| 英文格式: | ZHANG Ming-chen,LIN An,SANG Zhi-cheng,GE Lin.Causality between atopic diseases and osteoarthritis:a Mendelian randomization study[J].zhongguo gu shang / China J Orthop Trauma ,2024,37(9):904~909 |
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