| 正五聚蛋白3在骨质疏松和骨折愈合中的研究进展 |
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Received:July 19, 2021
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| 作者 | Author | 单位 | Unit | E-Mail |
| 鲁佳君 |
LU Jia-jun |
浙江中医药大学第一临床医学院, 浙江 杭州 310053 |
The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 孙岩 |
SUN Yan |
浙江中医药大学第一临床医学院, 浙江 杭州 310053 |
The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 张煊 |
ZHANG Xuan |
浙江中医药大学第一临床医学院, 浙江 杭州 310053 |
The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 王乔齐 |
WANG Qiao-qi |
浙江中医药大学附属第一医院, 浙江 杭州 310006 |
The First Affiliated Hospital of Zhejiang Chinese Medical Unversity, Hangzhou 310006, Zhejiang, China |
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| 项周益 |
XIANG Zhou-yi |
杭州市上城区清波街道社区卫生服务中心, 浙江 杭州 310002 |
Qingbo Street Community Health Service Center, Shangcheng District, Hangzhou, Hangzhou 310002, Zhejiang, China |
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| 凌奕清 |
LING Yi-qing |
浙江中医药大学附属第一医院, 浙江 杭州 310006 |
The First Affiliated Hospital of Zhejiang Chinese Medical Unversity, Hangzhou 310006, Zhejiang, China |
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| 童培建 |
TONG Pei-jian |
浙江中医药大学附属第一医院, 浙江 杭州 310006 |
The First Affiliated Hospital of Zhejiang Chinese Medical Unversity, Hangzhou 310006, Zhejiang, China |
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| 徐涛涛 |
XU Tao-tao |
浙江中医药大学附属第一医院, 浙江 杭州 310006 |
The First Affiliated Hospital of Zhejiang Chinese Medical Unversity, Hangzhou 310006, Zhejiang, China |
xut@zcmu.edu.cn |
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| 期刊信息：《中国骨伤》2023年36卷，第4期，第393-398页 |
| DOI：10.12200/j.issn.1003-0034.2023.04.018 |
| 基金项目:国家自然科学基金青年科学基金项目(编号:81904223)；浙江省医药卫生科技计划项目(面上项目)(编号:2020KY659)；白求恩公益基金会(编号:G-X-2020-1107-17)；浙江省科协"育才工程"项目(编号:CTZB-2020080127)；浙江中医药大学中青年科研创新基金(编号:KC201933)；浙江中医药大学校级科研基金(编号:2019ZR01) |
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| 正五聚蛋白3(pentraxin 3,PTX3)作为一种多功能糖蛋白,在调节炎症反应、促进组织损伤部位修复、诱导乳腺等骨外部位的异位钙化及维持骨内稳态等生理病理过程中发挥重要作用。其在骨密度中的影响可能受到多种因素的作用,在PTX3基因敲除小鼠及骨质疏松症(osteoporosis,OP)患者中,PTX3的缺失会导致骨密度的下降,而在韩国社区"Dong-gu研究"中则发现血浆PTX3水平与男性老年患者的股骨颈骨密度呈负相关。在骨相关细胞方面,对于成骨细胞(osteoblast,OB)来说,PTX3在维持OP状态下OB的表型与功能具有重要作用;对于破骨细胞(osteoclast,OC)来说,炎症状态下的PTX3可通过刺激核因子κB受体活化因子配体(receptor activator of nuclear factor-κB ligand,RANKL)生成及与TNF刺激基因6(TNF-stimulated gene 6,TSG-6)结合提高破骨细胞活性以促进骨吸收;对于间充质干细胞(mesenchymal stem cells,MSCs)来说,PTX3可通过PI3K/Akt信号通路促进MSCs的成骨分化。近年来,PTX3作为一种新的骨代谢调节因子,在OP和骨折愈合过程中的作用逐渐受到学者们的关注。在OP患者中,PTX3主要通过促进骨再生调节骨量;在骨折愈合过程中PTX3通过协调骨再生和骨吸收维持骨稳态以促进骨折愈合。鉴于PTX3以上生物学特性,其有望成为诊断和治疗OP等年龄相关骨疾病以及骨折愈合的新靶点。 |
| [关键词]:正五聚蛋白3 骨质疏松 骨折 成骨细胞 破骨细胞 |
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| Advances on pentraxin 3 in osteoporosis and fracture healing |
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| Abstract:Pentaxin 3 (PTX3),as a multifunctional glycoprotein,plays an important role in regulating inflammatory response,promoting tissue repair,inducing ectopic calcification and maintaining bone homeostasis. The effect of PTX3 on bone mineral density (BMD) may be affected by many factors. In PTX3 knockout mice and osteoporosis (OP) patients,the deletion of PTX3 will lead to decrease of BMD. In Korean community "Dong-gu study",it was found that plasma PTX3 was negatively correlated with BMD of femoral neck in male elderly patients. In terms of bone related cells,PTX3 plays an important role in maintaining the phenotype and function of osteoblasts (OB) in OP state;for osteoclast (OC),PTX3 in inflammatory state could stimulate nuclear factor κ receptor activator of nuclear factor-κB ligand (RANKL) production and its combination with TNF-stimulated gene 6(TSG-6) could improve activity of osteoclasts and promote bone resorption;for mesenchymal stem cells (MSCs),PTX3 could promote osteogenic differentiation of MSCs through PI3K/Akt signaling pathway. In recent years,the role of PTX3 as a new bone metabolism regulator in OP and fracture healing has been gradually concerned by scholars. In OP patients,PTX3 regulates bone mass mainly by promoting bone regeneration. In the process of fracture healing,PTX3 promotes fracture healing by coordinating bone regeneration and bone resorption to maintain bone homeostasis. In view of the above biological characteristics,PTX3 is expected to become a new target for the diagnosis and treatment of OP and other age-related bone diseases and fracture healing. |
| KEYWORDS:Pentraxin 3 Osteoporosis Fracture Osteoblast Osteoclast |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 鲁佳君,孙岩,张煊,王乔齐,项周益,凌奕清,童培建,徐涛涛.正五聚蛋白3在骨质疏松和骨折愈合中的研究进展[J].中国骨伤,2023,36(4):393~398 |
| 英文格式: | LU Jia-jun,SUN Yan,ZHANG Xuan,WANG Qiao-qi,XIANG Zhou-yi,LING Yi-qing,TONG Pei-jian,XU Tao-tao.Advances on pentraxin 3 in osteoporosis and fracture healing[J].zhongguo gu shang / China J Orthop Trauma ,2023,36(4):393~398 |
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