| NOD样受体蛋白1炎性小体在创伤性中枢神经损伤中的作用 |
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Received:March 16, 2021
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| 作者 | Author | 单位 | Unit | E-Mail |
| 李亚锋 |
LI Ya-feng |
北京中医药大学, 北京 100029 |
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| 移平 |
YI Ping |
中日友好医院, 北京 100029 |
China-Janan Friendship Hospital, Beijing 100029, China |
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| 王延雷 |
WANG Yan-lei |
北京中医药大学, 北京 100029 |
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| 吴鑫杰 |
WU Xin-jie |
中日友好医院, 北京 100029 |
China-Janan Friendship Hospital, Beijing 100029, China |
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| 杨峰 |
YANG Feng |
中日友好医院, 北京 100029 |
China-Janan Friendship Hospital, Beijing 100029, China |
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| 麻昊宁 |
MA Hao-ning |
中日友好医院, 北京 100029 |
China-Janan Friendship Hospital, Beijing 100029, China |
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| 谭明生 |
TAN Ming-sheng |
中日友好医院, 北京 100029 |
China-Janan Friendship Hospital, Beijing 100029, China |
zrtanms@sina.com |
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| 期刊信息：《中国骨伤》2021年34卷，第11期，第1058-1064页 |
| DOI：10.12200/j.issn.1003-0034.2021.11.014 |
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| NOD样受体蛋白1（NOD-like receptor protein 1，NLRP1）炎性小体在人体固有免疫反应中发挥着重要作用，可促进半胱氨酸蛋白水解酶（cysteinyl aspartate specific proteinases，Caspases）的活化，进一步激活白介素-18和白介素-1β，同时介导细胞焦亡，NLRP1炎性小体在创伤性中枢神经损伤中发挥着作用，本文就NLRP1炎性小体的结构、NLRP1炎性小体在创伤性中枢神经损伤中的激活以及以NLRP1炎性小体为靶点的治疗等方面进行了综述。 |
| [关键词]:NOD样受体蛋白1 创伤性中枢神经损伤 细胞焦亡 综述 |
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| Function of NOD-like receptor protein 1 inflammasome in traumatic central nervous system injury |
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| Abstract:NOD-like receptor protein 1 (NLRP1) inflammasome plays an important role in the innate immune response of human body. It can promote the activation of cysteinyl aspartate specific proteinases(Caspases), further activate interleukin-18 and interleukin-1 β, and mediate pyroptosis. NlRP1 inflammasome plays a role in traumatic central nervous system injury. In this study, the structure of NLRP1 inflammasome, the activation of NLRP1 inflammasome in traumatic central nervous system injury and the treatment with NLRP1 inflammasome as a target are reviewed. |
| KEYWORDS:NOD-like receptor protein 1 Traumatic central nervous system injury Pyroptosis Review |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 李亚锋,移平,王延雷,吴鑫杰,杨峰,麻昊宁,谭明生.NOD样受体蛋白1炎性小体在创伤性中枢神经损伤中的作用[J].中国骨伤,2021,34(11):1058~1064 |
| 英文格式: | LI Ya-feng,YI Ping,WANG Yan-lei,WU Xin-jie,YANG Feng,MA Hao-ning,TAN Ming-sheng.Function of NOD-like receptor protein 1 inflammasome in traumatic central nervous system injury[J].zhongguo gu shang / China J Orthop Trauma ,2021,34(11):1058~1064 |
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