| 程序性坏死在骨骼相关疾病中的研究进展 |
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Received:April 16, 2020
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| 作者 | Author | 单位 | Unit | E-Mail |
| 杨祖阁 |
YANG Zu-ge |
军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔疾病国际联合研究中心, 第四军医大学口腔医院口腔解剖生理学教研室, 陕西 西安 710032 |
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, Shaanxi, China |
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| 王若欣 |
WANG Ruo-xin |
郑州大学口腔医学院, 河南 郑州 450001 |
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| 任昊喆 |
REN Hao-zhe |
西安交通大学医学部, 陕西 西安 710061 |
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| 何峰 |
HE Feng |
军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔疾病国际联合研究中心, 第四军医大学口腔医院口腔解剖生理学教研室, 陕西 西安 710032 |
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, Shaanxi, China |
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| 马原军 |
MA Yuan-jun |
军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔疾病国际联合研究中心, 第四军医大学口腔医院口腔解剖生理学教研室, 陕西 西安 710032 |
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, Shaanxi, China |
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| 于世宾 |
YU Shi-bin |
军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔疾病国际联合研究中心, 第四军医大学口腔医院口腔解剖生理学教研室, 陕西 西安 710032 |
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, Shaanxi, China |
yushibin@fmmu.edu.cn |
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| 期刊信息：《中国骨伤》2021年34卷，第7期，第687-690页 |
| DOI：10.12200/j.issn.1003-0034.2021.07.020 |
| 基金项目:国家自然科学基金（编号：81970953）；陕西省重点研发计划一般项目（编号：2019SF-102） |
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| 程序性坏死（necroptosis） 是近年来发现的一种新型细胞死亡方式，主要由肿瘤坏死因子受体1（tumor necrosis factor receptor 1，TNFR1）启动，通过受体相互作用蛋白激酶1（receptor-interacting protein kinase 1，RIP1）和受体相互作用蛋白激酶3 （receptor-interacting protein kinase 3，RIP3）作用于混合系激酶区域样蛋白（mixed lineage kinase domain-like protein，MLKL）传递细胞死亡信号。程序性坏死发生后，细胞膜破裂，大量损伤相关分子模式（damage associated molecular patterns，DAMPs）进入周围组织，可以引发周围组织的反应，进而破坏组织稳态。近年来，大量研究表明细胞程序性坏死参与了骨质疏松、骨坏死、骨肉瘤等多种骨骼相关疾病的发生发展，本文试对这一领域的研究做一综述。 |
| [关键词]:程序性坏死 骨质疏松 骨肉瘤 骨坏死 骨髓 |
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| Research progress of necroptosis on bone related diseases |
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| Abstract:As a new type of cell death,necroptosis is initiated by tumor necrosis factor receptor 1(TNFR1),and then activated receptor-interacting protein kinase 1(RIP1) and receptor-interacting protein kinase 3 (RIP3),following by the activation of mixed lineage kinase domain-like protein(MLKL) to deliver cell death signal. When necroptosis happens,damage associated molecular patterns(DAMPs) enter into extracellular area through the ruptured cytomembrane,followed by the disordered tissue hemeostasis. In recent years,many researches showed that necroptosis play important roles in a few bone related diseases,such as osteoporosis,osteonecrosis,osteosarcoma,etc. Thus,we try to briefly review the researches in this field. |
| KEYWORDS:Necroptosis Osteoporosis Osteosarcoma Osteonecrosis Bone marrow |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 杨祖阁,王若欣,任昊喆,何峰,马原军,于世宾.程序性坏死在骨骼相关疾病中的研究进展[J].中国骨伤,2021,34(7):687~690 |
| 英文格式: | YANG Zu-ge,WANG Ruo-xin,REN Hao-zhe,HE Feng,MA Yuan-jun,YU Shi-bin.Research progress of necroptosis on bone related diseases[J].zhongguo gu shang / China J Orthop Trauma ,2021,34(7):687~690 |
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