| ATP6V1H基因在骨代谢中的作用 |
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Received:April 16, 2020
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| 作者 | Author | 单位 | Unit | E-Mail |
| 马锦锦 |
MA Jin-jin |
浙江中医药大学口腔医学院, 浙江杭州 310053 |
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 应俊 |
YING Jun |
浙江中医药大学第一临床医学院, 浙江杭州 310053
浙江省骨伤研究所, 浙江杭州 310053 |
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| 段小红 |
DUAN Xiao-hong |
空军军医大学口腔医院口腔生物学教研室军事口腔医学国家重点实验室, 陕西西安 710032 |
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| 肖鲁伟 |
XIAO Lu-wei |
浙江中医药大学第一临床医学院, 浙江杭州 310053
浙江省骨伤研究所, 浙江杭州 310053 |
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| 金红婷 |
JIN |
浙江中医药大学第一临床医学院, 浙江杭州 310053
浙江省骨伤研究所, 浙江杭州 310053 |
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| 冯剑颖 |
Hong-ting |
浙江中医药大学口腔医学院, 浙江杭州 310053 |
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
twohorsejy@163.com |
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| 期刊信息：《中国骨伤》2021年34卷，第3期，第265-268页 |
| DOI：10.12200/j.issn.1003-0034.2021.03.015 |
| 基金项目:国家自然科学基金（编号：81973869） |
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| 骨质疏松是临床常见的骨科疾病之一，能够导致多种并发症，该疾病致病因素较多，最新研究发现ATP6V1H是导致骨质疏松发生的新型基因，并很有可能成为未来药物治疗骨质疏松症的新靶点，其编码的蛋白是囊泡型ATP酶的H亚基。本文介绍了H亚基的生物学结构和特性，总结了因ATP6V1H部分缺失引起人体及动物模型如斑马鱼、小鼠骨量减少及骨密度降低等骨质疏松症状的相关研究报道，从破骨细胞、成骨细胞、骨髓基质细胞层面及其与各亚基之间的联系进一步阐述了H亚基调控骨动态平衡的机制，为探索ATP6V1H在骨发生发育及骨相关疾病方面奠定了基础，也为临床治疗骨质疏松提供新思路。 |
| [关键词]:ATP6V1H 骨质疏松 骨平衡 综述 |
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| Role of ATP6V1H gene in bone metabolism |
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| Abstract:Osteoporosis is one of the common clinical orthopedic diseases,which can lead to a variety of complications. There are many pathogenic factors in this disease. The latest research found that ATP6V1H is a new gene leading to the occurrence of osteoporosis,and it is likely to become a new target for the future drug treatment of osteoporosis.This paper introduces the biological structure and characteristics of H subunit,summed up the human body caused by loss of ATP6V1H and animal models such as zebrafish,mice bone loss and osteoporosis symptom such as related research reports of the loss,from osteoclast,osteoblast and marrow stromal cell level and the connection between the various subunits further expounds the H subunit regulate bone dynamic balance of mechanism,to explore ATP6V1H in bone development and bone related diseases has laid a solid foundation,also provide new ideas for clinical treatment of osteoporosis. |
| KEYWORDS:ATP6V1H Osteoporosis Bone balance Review |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 马锦锦,应俊,段小红,肖鲁伟,金红婷,冯剑颖.ATP6V1H基因在骨代谢中的作用[J].中国骨伤,2021,34(3):265~268 |
| 英文格式: | MA Jin-jin,YING Jun,DUAN Xiao-hong,XIAO Lu-wei,JIN,Hong-ting.Role of ATP6V1H gene in bone metabolism[J].zhongguo gu shang / China J Orthop Trauma ,2021,34(3):265~268 |
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