| 神经元胞外基质网络在脊髓损伤修复作用中的研究进展 |
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Received:March 19, 2020
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| 作者 | Author | 单位 | Unit | E-Mail |
| 胡蓉 |
HU Rong |
浙江中医药大学第三临床医学院, 浙江 杭州 310053 |
The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 徐海鹏 |
XU Hai-peng |
浙江中医药大学第三临床医学院, 浙江 杭州 310053 |
The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 何克林 |
HE Ke-lin |
浙江中医药大学第三临床医学院, 浙江 杭州 310053
浙江中医药大学附属第三医院针灸科, 浙江 杭州 310053 |
The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 陈怡 |
CHEN Yi |
浙江中医药大学第三临床医学院, 浙江 杭州 310053 |
The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 吴磊 |
WU Lei |
浙江中医药大学第三临床医学院, 浙江 杭州 310053
浙江中医药大学附属第三医院针灸科, 浙江 杭州 310053 |
The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 马睿杰 |
and MA Rui-jie |
浙江中医药大学第三临床医学院, 浙江 杭州 310053
浙江中医药大学附属第三医院针灸科, 浙江 杭州 310053 |
The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
maria7878@sina.Com |
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| 期刊信息：《中国骨伤》2021年34卷，第1期，第91-96页 |
| DOI：10.12200/j.issn.1003-0034.2021.01.017 |
| 基金项目:浙江省自然科学基金项目（编号：Y19H270050）；浙江省自然科学基金项目（编号：Q19H270020）；浙江省医药卫生科技项目（编号：2018KY56） |
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| 神经元胞外基质网络是由细胞外基质分子高度凝聚且环绕神经元形成的复杂的网络结构。在维持神经元性能、保护神经元免受有害物质的影响等方面起重要作用。然而，在脊髓损伤后，神经元胞外基质网络形成一道包裹在神经元外，限制神经可塑性的物理屏障，阻碍神经元轴突再生和髓鞘形成，同时，也会促进局部神经炎症吸收。本文主要阐述神经元胞外基质网络的组成、功能及其对脊髓损伤后轴突再生、髓鞘形成及神经炎症等方面的调节作用。 |
| [关键词]:脊髓损伤 神经元 轴突 髓鞘再生 |
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| Advances about perineuronal nets in the repair of nerve function after spinal cord injury |
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| Abstract:Perineuronal nets(PNNs) is a complex network composed of highly condensed extracellular matrix molecules surrounding neurons. It plays an important role in maintaining the performance of neurons and protecting them from harmful substances. However,after spinal cord injury,PNNs forms a physical barrier that surrounds the neuron and limits neuroplasticity,impedes axonal regeneration and myelin formation,and promotes local neuroinflammatory uptake. This paper mainly describes the composition and function of PNNs of neurons and its regulatory effects on axonal regeneration,myelin formation and neuroinflammation after spinal cord injury. |
| KEYWORDS:Spinal cord injuries Neurons Axons Remyelination |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 胡蓉,徐海鹏,何克林,陈怡,吴磊,马睿杰.神经元胞外基质网络在脊髓损伤修复作用中的研究进展[J].中国骨伤,2021,34(1):91~96 |
| 英文格式: | HU Rong,XU Hai-peng,HE Ke-lin,CHEN Yi,WU Lei,and MA Rui-jie.Advances about perineuronal nets in the repair of nerve function after spinal cord injury[J].zhongguo gu shang / China J Orthop Trauma ,2021,34(1):91~96 |
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