| 自体富血小板血浆联合植骨应用于诱导膜技术修复骨缺损 |
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Received:December 01, 2018
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| 作者 | Author | 单位 | Unit | E-Mail |
| 李树源 |
LI Shu yuan |
广州中医药大学第一附属医院骨科, 广东 广州 510405 |
Department of Orthopaedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
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| 周琦石 |
ZHOU Qi shi |
广州中医药大学第一附属医院骨科, 广东 广州 510405 |
Department of Orthopaedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
2410685058@qq.com |
| 李悦 |
LI Yue |
广州中医药大学第一附属医院骨科, 广东 广州 510405 |
Department of Orthopaedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
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| 陈超 |
CHEN Chao |
广州中医药大学第一附属医院骨科, 广东 广州 510405 |
Department of Orthopaedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
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| 陈家齐 |
CHEN Jia qi |
广州中医药大学第一附属医院骨科, 广东 广州 510405 |
Department of Orthopaedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
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| 周宏亮 |
ZHOU Hong liang |
广州中医药大学第一附属医院骨科, 广东 广州 510405 |
Department of Orthopaedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
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| 期刊信息：《中国骨伤》2019年32卷，第4期，第302-307页 |
| DOI：10.3969/j.issn.1003-0034.2019.04.003 |
| 基金项目:国家自然科学基金（编号：81674001） |
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目的：比较诱导膜技术Ⅱ期手术中，自体富血小板血浆联合植骨与单纯植骨在修复骨缺损方面的临床疗效。
方法：回顾性分析2013年1月至2017年9月采用诱导膜技术治疗的35例骨缺损患者的临床资料。根据手术方式不同分为富血小板血浆联合植骨治疗组（A组）和单纯植骨治疗组（B组）。A组18例，其中男11例，女7例；年龄17~61（40.4±13.4）岁；骨缺损长度3.6~18.0（9.5±4.4） cm。B组17例，其中男11例，女6例；年龄21~56（43.1±12.3）岁；骨缺损长度3.1~16.3（9.1±3.7） cm。比较两组的手术时间、术中出血量、骨临床愈合时间、骨愈合例数、感染发生例数及并发症例数。
结果：所有患者获得随访，时间13~39（21.3±1.2）个月。A组手术时间、术中出血量分别为（76.11±25.00） min、（78.89±14.91） ml，B组手术时间、术中出血量分别为（65.29±29.66） min、（79.41±20.45） ml，两组比较差异无统计学意义（P>0.05）。根据影像学结果评估，A组临床愈合时间为（28.78±9.40）周，B组为（36.17±9.68）周，两组比较差异有统计学意义（t=2.294，P=0.028）；A组愈合例数（17例）与B组（14例）比较差异无统计学意义（χ2=0.430，P=0.512）。A组1例发生感染，B组6例发生感染，两组比较差异有统计学意义（χ2=4.833，P=0.028）。A组2例发生并发症，B组9例发生并发症，两组比较差异有统计学意义（χ2=7.098，P=0.008）。
结论：在诱导膜技术Ⅱ期手术时，采用自体富血小板血浆联合植骨治疗骨缺损优势明显，可以缩短骨临床愈合时间，减少并发症的发生。 |
| [关键词]:富血小板血浆 骨移植 修复外科手术 |
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| Autologous platelet-rich plasma combined with bone grafting in inducing membrane technology |
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Abstract:
Objective:To compare clinical efficacy of autologous platelet-rich plasma combined with bone grafting and bone grafting in repairing bone defects on the second phase of induced membrane.
Methods:From January 2013 to September 2017,clinical data of 35 patients with bone defects treated by induced membrane technique were retrospectively analyzed. According to different surgical methods,the patients were divided into two groups. In group A,there were 18 patients,including 11 males and 7 females,aged from 17 to 61 years old with an average of(40.4±13.4) years old,the length of bone defect ranged from 3.6 to 18.0 cm with an average of (9.5±4.4) cm;and treated with platelet-rich plasma combined on the second-stage operation. In group B,there were 17 patients,including 11 males and 6 females,aged from 21 to 56 years old with an average of(43.1±12.3) years old,the length of bone defect ranged from 3.1 to 16.3 cm with an average of (9.1±3.7) cm;and treated with simple bone grafting. Operation time,amount of intraoperative blood loss,fracture healing time,the number of bone healing,the number of infection,and the number of complications were compared between two groups.
Results:All patients were followed up for 13 to 39 months with an average of(21.3±1.2) months. Operation time and blood loss in group A was(76.11±25.00) min,(78.89±14.91) ml,and in group B was (65.29±29.66) min,(79.41±20.45) ml;there were no statistical difference between two groups(P>0.05). According to imaging results,clinical healing time of bone in group A was (28.78±9.40) weeks,(36.17±9.68) weeks in group B,and had difference between two groups (t=2.294,P=0.028);there was no statistical difference in numbers of fracture healing between group A (17 cases) and group B (14 cases) (χ2=0.430,P=0.512). One patient in group A occurred infection and 6 patients in group B occurred infection,and had statistical difference between two groups (χ2=4.833,P=0.028). Two patients in group A occurred complications and 9 patients in group B occurred complications,which had difference between two groups (χ2=7.098,P=0.008).
Conclusion:In the induction membrane technique,autologous platelet-rich plasma combined with bone grafting has obvious advantages in treating bone defects,shortening fracture healing time and reducing incidence of complications. |
| KEYWORDS:Platelet-rich plasma Bone transplantation Reconstructive surgical procedures |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 李树源,周琦石,李悦,陈超,陈家齐,周宏亮.自体富血小板血浆联合植骨应用于诱导膜技术修复骨缺损[J].中国骨伤,2019,32(4):302~307 |
| 英文格式: | LI Shu yuan,ZHOU Qi shi,LI Yue,CHEN Chao,CHEN Jia qi,ZHOU Hong liang.Autologous platelet-rich plasma combined with bone grafting in inducing membrane technology[J].zhongguo gu shang / China J Orthop Trauma ,2019,32(4):302~307 |
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