| PFNA与InterTAN髓内钉治疗老年股骨转子间骨折疗效的Meta分析 |
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Received:May 20, 2018
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| 作者 | Author | 单位 | Unit | E-Mail |
| 于晨 |
YU Chen |
南京医科大学附属逸夫医院骨科, 江苏 南京 210000 |
Department of Orthopaedic, Sir Run Run Hospital, Nanjing Medical University, Nanjing 210000, Jiangsu, China |
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| 江龙海 |
JIANG Long-hai |
南京医科大学附属逸夫医院骨科, 江苏 南京 210000 |
Department of Orthopaedic, Sir Run Run Hospital, Nanjing Medical University, Nanjing 210000, Jiangsu, China |
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| 蔡大卫 |
CAI Da-wei |
南京医科大学附属逸夫医院骨科, 江苏 南京 210000 |
Department of Orthopaedic, Sir Run Run Hospital, Nanjing Medical University, Nanjing 210000, Jiangsu, China |
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| 吴积 |
WU Ji |
南京医科大学附属逸夫医院骨科, 江苏 南京 210000 |
Department of Orthopaedic, Sir Run Run Hospital, Nanjing Medical University, Nanjing 210000, Jiangsu, China |
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| 覃健 |
QIN Jian |
南京医科大学附属逸夫医院骨科, 江苏 南京 210000 |
Department of Orthopaedic, Sir Run Run Hospital, Nanjing Medical University, Nanjing 210000, Jiangsu, China |
qinjian@njmu.edu.cn |
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| 期刊信息：《中国骨伤》2019年32卷，第2期，第120-129页 |
| DOI：10.3969/j.issn.1003-0034.2019.02.006 |
| 基金项目:南京医科大学校基金面上项目（编号：2017NJMU224） |
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目的：比较股骨近端防旋髓内钉PFNA与InterTAN髓内钉治疗老年股骨转子间骨折的临床疗效。
方法：检索Cochrane、PubMed等数据库中，所有关于比较PFNA与InterTAN治疗老年股骨转子间骨折临床效果的随机对照实验（RCT）的文献，检索时限为建库至2018年1月20日。由2位评价者独立阅读筛选文献、提取资料和评价质量，用RevMan 5.3软件进行Meta分析，GRADEpro系统评价证据质量及推荐等级。
结果：共纳入12个研究，1 015例患者。Meta分析结果显示：安全性：与InterTAN相比，PFNA手术时间较短、术中出血量较少，而InterTAN术后总并发症发生率更低、术后内固定失败情况更少，而切口长度、术后骨折愈合时间以及其他术后并发症两者差异无统计学意义。有效性：术后3个月PFNA髋关节Harris评分低于InterTAN；而术后6、12个月Harris评分差异均无统计学意义。应用GRADEpro系统评价显示：证据质量分级均为低级，弱推荐。
结论：PFNA与InterTAN相比，两者的临床疗效相似，而InterTAN能提供更好的抗旋转稳定及轴向加压作用，可以让患者更早下床活动锻炼、恢复髋关节功能。且InterTAN术后并发症、内固定失败相对更少。但受纳入研究的质量和数量所限制，需要更多高质量、大样本RCT加以验证，对于老年股骨转子间骨折手术方式的选择应综合考虑患者的年龄、骨质情况、骨折类型以及合并症做出合理选择。 |
| [关键词]:股骨 髋骨折 骨折固定术,内 Meta分析 |
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| PFNA and InterTAN intramedullary nailing in elderly patients with femoral intertrochanteric fractures: a Meta analysis |
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Abstract:
Objective: To evaluate the efficacy and safety of proximal femoral nail antirotation (PFNA) vs InterTAN nail in treating the elderly intertrochanteric femoral fractures.
Methods: Data of the randomized controlled trials (RCTs) about PFNA vs InterTAN for the treatment of the elderly intertrochanteric femoral fractures were searched in as the Cochrane Library, PubMed, EMbase, Wanfang, CNKI, CBM and VIP from their establishment to January 2018 for collecting. After study selection, assessment and data extraction conducted by two reviewers independently, meta-analyses were performed by using the RevMan 5.3 sofware. The level of evidence was assessed by using the GRADEpro system.
Results: Twelve studies involving 1 015 patients were included. The results of meta, analyses showed that:(1)safety indicator:compared with the InterTAN, PFNA had shorter operation time, and less intraoperative bleeding. But InterTAN had less total postoperative complications and internal fixation failure, but there was no significant difference in the operative incision lengths, fracture healing time and other postoperative complications. (2)efficacy indicator:compared with the InterTAN, the Harris hip score was lower after 3 months, but Harris hip score had no significant difference between the two groups after 6, 12 months. Based on GRADEpro system, all the evidence was at level C and weak recommendation (2C).
Conclusion: The current evidence indicates that PFNA had a similar effect compared with the InterTAN. But InterTAN could provide better stability against rotation and axial pressure effect, can allow patients do functional exercise early such as ambulation to recovery the hip function. It also had less total postoperative complications and internal fixation failure for the poor quality of the original studies and the limited number of studies, a prudent choice is suggested and more high-quality, large-sample studies are need. |
| KEYWORDS:Femur Hip fractures Fracture fixation,internal Meta analysis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 于晨,江龙海,蔡大卫,吴积,覃健.PFNA与InterTAN髓内钉治疗老年股骨转子间骨折疗效的Meta分析[J].中国骨伤,2019,32(2):120~129 |
| 英文格式: | YU Chen,JIANG Long-hai,CAI Da-wei,WU Ji,QIN Jian.PFNA and InterTAN intramedullary nailing in elderly patients with femoral intertrochanteric fractures: a Meta analysis[J].zhongguo gu shang / China J Orthop Trauma ,2019,32(2):120~129 |
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