| Ⅸ型胶原基因与骨肌系统疾病相关性的研究现状 |
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Received:January 30, 2018
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| 作者 | Author | 单位 | Unit | E-Mail |
| 董睿 |
DONG Rui |
浙江中医药大学第一临床医学院, 浙江 杭州 310053 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 吴运瑶 |
WU Yun-yao |
江西中医药大学附属医院, 江西 南昌 330046 |
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| 方亮 |
FANG Liang |
浙江中医药大学第一临床医学院, 浙江 杭州 310053 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 应俊 |
YING Jun |
浙江中医药大学第一临床医学院, 浙江 杭州 310053 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 张磊 |
ZHANG Lei |
浙江中医药大学第一临床医学院, 浙江 杭州 310053 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 许世兵 |
XU Shi-bing |
浙江中医药大学第一临床医学院, 浙江 杭州 310053 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 王萍儿 |
WANG Ping-er |
浙江中医药大学第一临床医学院, 浙江 杭州 310053
浙江省骨伤研究所, 浙江 杭州 310053
浙江中医药大学附属第一医院, 浙江 杭州 310006 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 金红婷 |
JIN Hong-ting |
浙江中医药大学第一临床医学院, 浙江 杭州 310053
浙江省骨伤研究所, 浙江 杭州 310053
浙江中医药大学附属第一医院, 浙江 杭州 310006 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 肖鲁伟 |
XIAO Lu-wei |
浙江中医药大学第一临床医学院, 浙江 杭州 310053
浙江省骨伤研究所, 浙江 杭州 310053
浙江中医药大学附属第一医院, 浙江 杭州 310006 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
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| 童培建 |
TONG Pei-Jian |
浙江中医药大学第一临床医学院, 浙江 杭州 310053
浙江省骨伤研究所, 浙江 杭州 310053
浙江中医药大学附属第一医院, 浙江 杭州 310006 |
The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China |
tongpeijian@163.com |
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| 期刊信息：《中国骨伤》2019年32卷，第1期，第92-96页 |
| DOI：10.3969/j.issn.1003-0034.2019.01.021 |
| 基金项目:国家自然科学基金面上项目（编号：81774332）；浙江省科技厅十二五重大专项（编号：2014C13G2120082）；浙江省中医药管理局重点项目（编号：2018ZZ011）；浙江省中医药管理局面上项目（编号：2018ZA034） |
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| Ⅸ型胶原作为关节软骨的一个重要组成部分，对骨与软骨稳态起着重要的调控作用。该基因变异或缺失会引起这个稳态失衡从而导致相应骨关节结构发育异常，导致多发性骨骺发育不全。解剖结构的变异随之而来的是相应功能单位的生物学性能改变，结合由基因异常引起的微环境改变，在反复应力的作用下会出现骨关节炎、椎间盘退行性变等一系列骨关节退行性变，此外，Ⅸ型胶原的缺乏还影响关节软骨、椎间盘组织损伤的修复。然而，与Ⅸ型胶原基因相关的骨肌系统疾病不仅限于此，还有许多疾病报道较少，证据相对不足，有待进一步深入研究。明确该基因与这些疾病的关系不仅可以提供有效的诊断方法，更能为后续的治疗开辟新的道路。 |
| [关键词]:胶原Ⅸ型 基因 软骨 综述 |
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| Research status of correlation between type Ⅸ collagen gene and musculoskeletal diseases |
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| Abstract:As an important component of articular cartilage,type Ⅸ collagen plays an important role in regulating homeostasis of bone and cartilage. The mutation or deletion of gene could disequilibrate homeostasis leads to deformity of corresponding bone and joint,and finally causes multiple epiphyseal dysplasia. Moreover,anatomic variation also leads to biomechanics change of corresponding functional unit,combine with micro-environment change caused by change of genes,osteoarthritis and disc degeneration were occurred under the function of stress over and over again. In addition,lack of type Ⅸ collagen could effect repair of articular cartilage,intervertebral disc tissue injury. However,musculoskeletal diseases related with type Ⅸ collagen has so much not limited this,the reports about it is less for lack of evidence,and need further work to study. Clear relationship of type Ⅸ collagen and its disease could provide an effective diagnostic method,and develop a new pathway for follow-up treatment. |
| KEYWORDS:Collagen type Ⅸ Genes Cartilage Review |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 董睿,吴运瑶,方亮,应俊,张磊,许世兵,王萍儿,金红婷,肖鲁伟,童培建.Ⅸ型胶原基因与骨肌系统疾病相关性的研究现状[J].中国骨伤,2019,32(1):92~96 |
| 英文格式: | DONG Rui,WU Yun-yao,FANG Liang,YING Jun,ZHANG Lei,XU Shi-bing,WANG Ping-er,JIN Hong-ting,XIAO Lu-wei,TONG Pei-Jian.Research status of correlation between type Ⅸ collagen gene and musculoskeletal diseases[J].zhongguo gu shang / China J Orthop Trauma ,2019,32(1):92~96 |
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