| 长链非编码234对骨组织代谢影响的研究进展 |
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Received:February 19, 2017
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| 作者 | Author | 单位 | Unit | E-Mail |
| 郭铁峰 |
GUO Tie-feng |
甘肃省中医院, 甘肃 兰州 730030 |
Gansu Provincial Hospital of TCM, Lanzhou 730030, Gansu, China |
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| 周明旺 |
ZHOU Ming-wang |
甘肃省中医院, 甘肃 兰州 730030 |
Gansu Provincial Hospital of TCM, Lanzhou 730030, Gansu, China |
923433675@qq.com |
| 李盛华 |
LI Sheng-hua |
甘肃省中医院, 甘肃 兰州 730030 |
Gansu Provincial Hospital of TCM, Lanzhou 730030, Gansu, China |
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| 叶丙霖 |
YE Bing-lin |
甘肃省中医院, 甘肃 兰州 730030 |
Gansu Provincial Hospital of TCM, Lanzhou 730030, Gansu, China |
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| 陈威 |
CHEN Wei |
甘肃省中医院, 甘肃 兰州 730030 |
Gansu Provincial Hospital of TCM, Lanzhou 730030, Gansu, China |
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| 付志斌 |
FU Zhi-bin |
甘肃省中医院, 甘肃 兰州 730030 |
Gansu Provincial Hospital of TCM, Lanzhou 730030, Gansu, China |
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| 期刊信息：《中国骨伤》2018年31卷，第3期，第286-291页 |
| DOI：10.3969/j.issn.1003-0034.2018.03.020 |
| 基金项目:国家自然基金项目（编号：81473712） |
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| 骨与软骨的代谢机制一直是骨科领域的研究热点之一，其临床及基础研究在骨质疏松、骨关节退变、骨肿瘤等骨科疑难疾病的防治方面发挥了至关重要的作用。目前，随着基因技术的发展，相关机制的研究已经从蛋白、信号通路水平，逐步深入至mRNA转录因子的调控水平。长链非编码RNA（Long non-coding RNA，LncRNA）作为非编码蛋白质的新型基因表达调控因子，在转录调控水平参与了生物的各种生理及病理过程。近年来，大量研究表明LncRNA在骨与软骨代谢中起重要作用，并证实其参与了多种骨代谢疾病的发生、发展及转归过程，随着LncRNA作用途径及靶点不断地被发现，其在骨代谢中的关键地位被不断证实。本文通过总结LncRNA的生物学特性，及其在骨与软骨代谢中的作用和相关靶点，进一步阐释骨与软骨代谢的基因调控机制，探讨了其在诊断和治疗骨代谢性疾病中的重要价值，为骨代谢性疾病的防治提供了新的思路及治疗靶点。 |
| [关键词]:骨和骨组织 代谢 综述文献 |
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| Long non-coding RNA for metabolism of bone tissue |
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| Abstract:The mechanism of metabolism of bone and cartilage are one of focus of orthopedic knowledge,and its clinical and basic study plays an important role in preventing and treating osteoporosis,degeneration of bone and joint,bone tumor. At present,the mechanism of metabolism of bone and cartilage studied from protein,signal pathway to mRNA transcription factor regulation. As a new regulatory factor for non-coding proteins,long non-coding RNA(LncRNA) participates in physiological and pathological process. In recent years,a large number of researche showed that LncRNA plays an important role in metabolism of bone and cartilage,and proved LncRNA participates in development and conversion of bone metabolism. With the exposure of function chennel and target of LncRNA,the key role of LncRNA in bone metabolism were proved constantly. The paper concluded biological characteristics of LncRNA,function and target spot of LncRNA in bone and cratilage metabolism,and in further state gene regulatory mechanism of bone and cartilage metabolism,explore diagnosis and treatment,provide new thought and treatment target for bone metabolism. |
| KEYWORDS:Bone and bones Metabolism Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 郭铁峰,周明旺,李盛华,叶丙霖,陈威,付志斌.长链非编码234对骨组织代谢影响的研究进展[J].中国骨伤,2018,31(3):286~291 |
| 英文格式: | GUO Tie-feng,ZHOU Ming-wang,LI Sheng-hua,YE Bing-lin,CHEN Wei,FU Zhi-bin.Long non-coding RNA for metabolism of bone tissue[J].zhongguo gu shang / China J Orthop Trauma ,2018,31(3):286~291 |
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