| 巨噬细胞极化在脊髓损伤中的作用机制 |
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Received:March 20, 2017
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| 作者 | Author | 单位 | Unit | E-Mail |
| 徐保平 |
XU Bao-ping |
上海中医药大学附属龙华医院, 上海 200032
上海中医药大学脊柱病研究所, 上海 200032 |
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| 姚敏 |
YAO Min |
上海中医药大学附属龙华医院, 上海 200032
上海中医药大学脊柱病研究所, 上海 200032 |
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| 王晓涛 |
WANG Xiao-tao |
上海中医药大学附属龙华医院, 上海 200032
上海中医药大学脊柱病研究所, 上海 200032 |
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| 杨龙 |
YANG Long |
上海中医药大学脊柱病研究所, 上海 200032 |
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| 田子睿 |
TIAN Zi-rui |
上海中医药大学附属龙华医院, 上海 200032
上海中医药大学脊柱病研究所, 上海 200032 |
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| 潘艳芳 |
PAN Yan-fang |
上海中医药大学附属龙华医院, 上海 200032
上海中医药大学脊柱病研究所, 上海 200032 |
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| 崔学军 |
CUI Xue-jun |
上海中医药大学附属龙华医院, 上海 200032
上海中医药大学脊柱病研究所, 上海 200032 |
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
13917715524@139.com |
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| 期刊信息：《中国骨伤》2018年31卷，第1期，第88-92页 |
| DOI：10.3969/j.issn.1003-0034.2018.01.017 |
| 基金项目:上海市科委中医重点项目（编号：14401970400）；上海市科委中医药领域中医重点项目（编号：15401972000）；筋骨理论与治法教育部重点实验室（编号：教科<2009>98号）；国家科技部重点领域创新团队计划项目（编号：2015RA4002） |
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| 脊髓损伤是脊柱神经系统严重的创伤，损伤后局部组织破坏和微循环障碍，引起局部损伤加重和周围神经细胞广泛坏死。脊髓损伤后常常伴随炎症反应产生各种细胞因子和生物活性物质，引起巨噬细胞极化，巨噬细胞在IFN-γ、LPS、TNF-α等刺激极化成M1巨噬细胞，主要表现为促炎和损伤作用；在IL-4、IL-10、IL-13刺激下极化为M2巨噬细胞，主要表现出抗炎和修复作用。目前脊髓损伤后的治疗手段非常有限，通过调控脊髓损伤后M1和M2巨噬细胞抑制其促炎损伤作用，促进神经修复作用是脊髓损伤后治疗的一个新方向。本文将对巨噬细胞在脊髓损伤后的极化表型及其功能特点的研究进展做一综述。 |
| [关键词]:脊髓损伤 巨噬细胞 综述文献 |
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| Mechanism of macrophage polarization on spinal cord injury |
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| Abstract:Spinal cord injury is a serious trauma of the spinal and nervous system,local tissue destruction and microcirculation disturbance can lead to a more serious spinal cord injury and extensive necrosis of neurons. Spinal cord injury often accompany with Inflammation reaction producing a variety of cytokines and bioactive substances,result in macrophage polarization. M1 macrophages polarization are induced by IFN-γ,LPS,TNF-α and so on,it show the damage and proinflammatory effect. M2 macrophages polarization are caused by IL-4,IL-10,IL-13 and show the recovery and anti-inflammatory effect. However,clinical treatment after spinal cord injury is very limited,inhibition of proinflammatory and promotion of anti-inflammatory by regulating the M1 macrophages and M2 macrophages is a new direction for the treatment of spinal cord injury. The article will review different phenotype and function of macrophages after spinal cord injury. |
| KEYWORDS:Spinal cord injury Macrophage Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 徐保平,姚敏,王晓涛,杨龙,田子睿,潘艳芳,崔学军.巨噬细胞极化在脊髓损伤中的作用机制[J].中国骨伤,2018,31(1):88~92 |
| 英文格式: | XU Bao-ping,YAO Min,WANG Xiao-tao,YANG Long,TIAN Zi-rui,PAN Yan-fang,CUI Xue-jun.Mechanism of macrophage polarization on spinal cord injury[J].zhongguo gu shang / China J Orthop Trauma ,2018,31(1):88~92 |
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