| 不同来源间充质干细胞在膝关节软骨修复中的临床研究进展 |
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Received:August 27, 2016
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| 作者 | Author | 单位 | Unit | E-Mail |
| 王连 |
WANG Lian |
安徽中医药大学针灸骨伤临床学院, 安徽 合肥 230038 |
Clinical School of Acupuncture and Orthopaedics, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China |
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| 侯鹏 |
HOU Peng |
安徽中医药大学针灸骨伤临床学院, 安徽 合肥 230038 |
Clinical School of Acupuncture and Orthopaedics, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China |
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| 蒋涛 |
JIANG Tao |
安徽中医药大学针灸骨伤临床学院, 安徽 合肥 230038 |
Clinical School of Acupuncture and Orthopaedics, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China |
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| 汪宗保 |
WANG Zong-bao |
安徽中医药大学针灸骨伤临床学院, 安徽 合肥 230038 |
Clinical School of Acupuncture and Orthopaedics, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China |
673099692@qq.com |
| 赵银学 |
ZHAO Yin-xue |
安徽中医药大学针灸骨伤临床学院, 安徽 合肥 230038 |
Clinical School of Acupuncture and Orthopaedics, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China |
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| 吴可 |
WU Ke |
安徽中医药大学中医临床学院, 安徽 合肥 230038 |
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| 期刊信息：《中国骨伤》2017年30卷，第6期，第581-586页 |
| DOI：10.3969/j.issn.1003-0034.2017.06.020 |
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| 近年来由于器官修复干细胞治疗技术的提出，使得不能自身修复的关节软骨成为研究热点之一，间充质干细胞对膝关节软骨修复已表现出明显的治疗优势。学者们临床上初步研究了不同来源的间充质干细胞膝关节软骨修复作用，并通过结合移植、软骨组织工程等技术提高了骨髓、脂肪、滑膜、脐带血等来源干细胞修复人类软骨效果，均取得了较好的临床疗效。不同干细胞来源不同各自会有一定的优缺点。目前临床研究仍处于试验阶段，尚无确切定论何种干细胞及何种技术处理最适合于人类软骨的修复。大规模和或结合新处理技术的临床试验以及远期疗效的验证，需要进一步临床深入研究。 |
| [关键词]:干细胞 膝关节 软骨 修复外科手术 |
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| Different sources of mesenchymal stem cells for the treatment of cartilage repair in knee joint |
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| Abstract:As propose of organ repair stem cell therapy technology,articular cartilage cannot be repaired by itself has become one of the research hotspots,repair of articular cartilage with mesenchymal stem cells has shown obvious advantages for the treatment. The scholars have made a preliminary study on the role of mesenchymal stem cells from different sources in the repair of knee articular cartilage,and with the combination of transplantation and cartilage tissue engineering,these technologies improved the human cartilage repair effect of bone marrow,adipose,synovium,cord blood derived stem cells,which achieved good clinical curative effect. Due to the different sources,the dominant and recessive factors,each stem cell will have certain advantages and disadvantages. At present,the clinical research is still in the experimental stage,there is no definite conclusion on which kind of stem cell or technology is more suitable for human cartilage repair. This requires the validation of large-scale or combining with new processing technology clinical trials and the long-term clinical effect,it also provides for the basis for further clinical research. |
| KEYWORDS:Stem cells Knee joint Cartilage Reconstructive surgical procedures |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 王连,侯鹏,蒋涛,汪宗保,赵银学,吴可.不同来源间充质干细胞在膝关节软骨修复中的临床研究进展[J].中国骨伤,2017,30(6):581~586 |
| 英文格式: | WANG Lian,HOU Peng,JIANG Tao,WANG Zong-bao,ZHAO Yin-xue,WU Ke.Different sources of mesenchymal stem cells for the treatment of cartilage repair in knee joint[J].zhongguo gu shang / China J Orthop Trauma ,2017,30(6):581~586 |
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