| 椎间盘退变生物学治疗的研究进展 |
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Received:October 19, 2015
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| 作者 | Author | 单位 | Unit | E-Mail |
| 蒋家耀 |
JIANG Jia-yao |
第二军医大学附属长征医院骨科, 上海 200003 |
Department of Orthopaedics, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China |
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| 卢旭华 |
LU Xu-hua |
第二军医大学附属长征医院骨科, 上海 200003 |
Department of Orthopaedics, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China |
xuhualu@hotmail.com |
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| 期刊信息：《中国骨伤》2016年29卷，第6期，第576-580页 |
| DOI：10.3969/j.issn.1003-0034.2016.06.020 |
| 基金项目:国家自然科学基金项目(编号:81171754) |
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| 椎间盘退变所致的颈肩腰腿痛严重影响许多患者的生活及工作,目前的治疗方法主要侧重于缓解疼痛症状或神经受压症状,而无法阻止椎间盘退变的进程,导致疾病具有高复发率。近年来学者们开始广泛研究椎间盘退变的生物学治疗方法,即通过生物分子治疗、基因治疗、细胞治疗和组织工程等方法来修复和重塑椎间盘,以期从根本上解决椎间盘退变的问题,而上述方法大多处于动物实验或体外实验阶段,临床应用尚存在诸多挑战。 |
| [关键词]:椎间盘 生物学 综述文献 |
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| Biological treatment for intervertebral disc degeneration |
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| Abstract:Neck shoulder pain or lumbocrural pain caused by intervertebral disc degeneration(IDD) could seriously affect the qualities life of patients. Current treatments mainly focus on alleviating pain and the symptoms of nerve compression,which could not radically stop the process of intervertebral disc degeneration,but conversely lead to high recurrence rate. In recent years,scholars have turned to study the biological treatment for repair and rebuild the intervertebral disc by biological molecular therapy,gene therapy,cell therapy and tissue engineering to solve the problem of intervertebral disc degeneration,while most of the above methods are still in animal experiments or in vitro experiments and the clinical application is still a long way to go. |
| KEYWORDS:Intervertebral disk Biology Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 蒋家耀,卢旭华.椎间盘退变生物学治疗的研究进展[J].中国骨伤,2016,29(6):576~580 |
| 英文格式: | JIANG Jia-yao,LU Xu-hua.Biological treatment for intervertebral disc degeneration[J].zhongguo gu shang / China J Orthop Trauma ,2016,29(6):576~580 |
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