| 细胞自噬在脊髓损伤中作用的研究进展 |
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Received:August 27, 2014
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| 作者 | Author | 单位 | Unit | E-Mail |
| 周凯亮 |
ZHOU Kai-liang |
温州医科大学附属第二医院脊柱外科, 浙江 温州 325000 |
Department of Spinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China |
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| 张小磊 |
ZHANG Xiao-lei |
温州医科大学附属第二医院脊柱外科, 浙江 温州 325000 |
Department of Spinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China |
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| 吴凯 |
WU Kai |
温州医科大学附属第二医院脊柱外科, 浙江 温州 325000 |
Department of Spinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China |
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| 王雍立 |
WANG Yong-li |
温州医科大学附属第二医院脊柱外科, 浙江 温州 325000 |
Department of Spinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China |
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| 徐华梓 |
XU Hua-zi |
温州医科大学附属第二医院脊柱外科, 浙江 温州 325000 |
Department of Spinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China |
spinexu@163.com |
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| 期刊信息：《中国骨伤》2015年28卷，第8期，第695-698页 |
| DOI：10.3969/j.issn.1003-0034.2015.08.004 |
| 基金项目:国家自然科学基金(编号:81401871,81401162);浙江省医药卫生科技项目(编号:2013KYA127) |
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| 近年来,细胞自噬在脊髓损伤中的研究逐渐成为热点,但脊髓损伤后早期自噬激活所起的作用尚有争议。其原因在于细胞自噬在脊髓损伤中的作用具有两面性:一方面自噬能诱导自噬性细胞死亡的发生并参与细胞凋亡的发生,另一方面自噬能促进受损变性蛋白的代谢以及抑制细胞凋亡。然而究其对脊髓损伤后修复的利弊作用,早期自噬激活的程度具有决定作用,脊髓损伤后适当地上调自噬水平可促进受损变性蛋白的代谢并抑制细胞凋亡,而过度激活自噬可能引发自噬性细胞死亡。 |
| [关键词]:脊髓损伤 细胞自噬 综述文献 |
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| Progress on the role of autophagy in spinal cord injury |
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| Abstract:In recent years,the study of autophagy in spinal cord injury(SCI)gradually becomes the hot spot. However,the function of autophagy in the injured spinal cord is still controversial. In order to further understand the role of autophagy after SCI,we summarized the activation of autophagy,autophagic cell death,the relationship between autophagy and apoptosis,the function of autophagy in promoting the molecular metabolism and the role of autophagy after spinal cord injury. We concluded that the role of autophagy after SCI is a double-edged sword. Upregulating the level of autophagy appropriately can promote damaged proteins metabolism and inhibit apoptosis,However,excessive activation of antophagy may induce autophagic cell dealth. So we consider that the proper regulation of autophagy will be a new target in the treatment of SCI. |
| KEYWORDS:Spinal cord injury Autophagy Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 周凯亮,张小磊,吴凯,王雍立,徐华梓.细胞自噬在脊髓损伤中作用的研究进展[J].中国骨伤,2015,28(8):695~698 |
| 英文格式: | ZHOU Kai-liang,ZHANG Xiao-lei,WU Kai,WANG Yong-li,XU Hua-zi.Progress on the role of autophagy in spinal cord injury[J].zhongguo gu shang / China J Orthop Trauma ,2015,28(8):695~698 |
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