| 锂剂治疗脊髓损伤机制的研究进展 |
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Received:May 20, 2014
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| 作者 | Author | 单位 | Unit | E-Mail |
| 张舵 |
ZHANG Duo |
西安交通大学第二附属医院骨二科, 陕西 西安 710004 |
The Second Department of Orthopaedics, the Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China |
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| 贺西京 |
HE Xi-jing |
西安交通大学第二附属医院骨二科, 陕西 西安 710004 |
The Second Department of Orthopaedics, the Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China |
xijing_h@vip.tom.com |
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| 期刊信息：《中国骨伤》2015年28卷，第7期，第679-682页 |
| DOI：10.3969/j.issn.1003-0034.2015.07.023 |
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| 脊髓损伤是由一系列内外因素所造成的骨科及神经科学领域严重的致残性疾病,是目前医学界的一大难题。锂剂作为治疗双相情感障碍的主要药物已有100多年的历史。研究证实锂剂对脑神经元有保护作用,其对脊髓损伤的治疗作用也渐渐被观察到。锂剂能够通过保护神经元完整、减少损伤后炎症反应、促进神经营养因子的生成和释放、刺激神经发生以及促进自噬、抑制凋亡等机制达到治疗脊髓损伤的目的。通过回顾有关锂剂对神经系统作用的研究,总结分析了锂剂治疗脊髓损伤作用机制的研究进展,以锂剂为基础的综合治疗具有良好的应用前景。 |
| [关键词]:脊髓损伤 锂剂 作用机制 |
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| Advances in mechanisms of treatment for spinal cord injury with lithium |
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| Abstract:Spinal cord injury is a serious disabling disease caused by a series of internal and external factors in the field of orthopaedics and neuroscience,which is a big problem for doctors all over the world. Lithium has been used to treat dipolar disorder for over 100 years. It has been reported that lithium is benefit for brain neuron. The treatment effect for spinal cord injury gets more and more attention. Researches indicate that lithium is benefit for spinal cord injury by protecting neuron,reducing after-injury inflammation,increasing the produce and release of neurotrophins,stimulating neurogenesis,enhancing autophagy and inhibiting apoptosis. This article summaries advances in mechanism of treatment for spinal cord injury with lithium by reviewing and analyzing researches. Therapy combined with lithium has a good application prospect. |
| KEYWORDS:Spinal cord injury Lithium Mechanism |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 张舵,贺西京.锂剂治疗脊髓损伤机制的研究进展[J].中国骨伤,2015,28(7):679~682 |
| 英文格式: | ZHANG Duo,HE Xi-jing.Advances in mechanisms of treatment for spinal cord injury with lithium[J].zhongguo gu shang / China J Orthop Trauma ,2015,28(7):679~682 |
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