| 不同强度正弦交变电磁场对大鼠骨密度及骨形态计量学的影响 |
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Received:January 30, 2014
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| 作者 | Author | 单位 | Unit | E-Mail |
| 高玉海 |
GAO Yu-hai |
兰州军区兰州总医院骨科研究所, 甘肃 兰州 730050 |
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, Gansu, China |
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| 成魁 |
CHENG Kui |
兰州军区兰州总医院骨科研究所, 甘肃 兰州 730050 |
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, Gansu, China |
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| 葛宝丰 |
GE Bao-feng |
兰州军区兰州总医院骨科研究所, 甘肃 兰州 730050 |
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, Gansu, China |
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| 甄平 |
ZHEN Ping |
兰州军区兰州总医院骨科研究所, 甘肃 兰州 730050 |
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, Gansu, China |
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| 周建 |
ZHOU Jian |
兰州军区兰州总医院骨科研究所, 甘肃 兰州 730050 |
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, Gansu, China |
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| 马小妮 |
MA Xiao-ni |
兰州军区兰州总医院骨科研究所, 甘肃 兰州 730050 |
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, Gansu, China |
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| 李少锋 |
LI Shao-feng |
兰州军区兰州总医院骨科研究所, 甘肃 兰州 730050 |
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, Gansu, China |
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| 陈克明 |
CHEN Ke-ming |
兰州军区兰州总医院骨科研究所, 甘肃 兰州 730050 |
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, Gansu, China |
Chkeming@126.com |
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| 期刊信息：《中国骨伤》2014年27卷，第11期，第933-937页 |
| DOI：10.3969/j.issn.1003-0034.2014.11.012 |
| 基金项目:国家自然科学基金(编号;81270963);甘肃省科技重大专项计划资助项目(编号;092NKDA025) |
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目的: 研究50 Hz 不同强度正弦交变电磁场(sinusoidal electromagnetic fields,SEMFs)对SD大鼠骨密度和骨形态计量学的影响.
方法: 将30只雌性SD大鼠随机分为3组：A组(正常对照组),B组(0.1 mT磁场组)和C组(0.6 mT磁场组).除对照组外,分别给予各磁场组每日3 h的磁场干预.实验8周后处死大鼠,用双能X线骨密度仪检测各组大鼠全身、股骨及椎体骨密度,并对左侧胫骨及椎体L4分别进行骨组织静态和动态分析评价.
结果: 与A组相比,B组大鼠全身、股骨和椎体骨密度显着增加;股骨和椎体骨小梁面积百分数、骨小梁数量和骨小梁宽度显着增加,骨小梁分离度明显降低;观察双标记有明显变化.C组骨小梁数目与A组相比差异有统计学意义,其余指标差异均无统计学意义.
结论: 50 Hz 0.1 mT磁场强度的正弦交变电磁场,能够有效增加大鼠骨密度,改善大鼠的骨组织微结构,促进骨形成. |
| [关键词]:电磁场 骨密度 骨和骨组织 大鼠 |
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| Effect of different-intensity SEMFs on bone mineral density and histomorphometry in SD rats |
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Abstract:
Objective: To investigate the effects of different-intensity sinusoidal electromagnetic fields(SEMFs) on bone mineral density(BMD) and histomorphometry in SD rats.
Methods: Thirty female SD rats were randomly divided into three groups:group A(a control group),group B(0.1 mT group) and group C(0.6 mT group). The rats in group B and C were exposed to 50 Hz SEMFs 3 hours each day. However,the magnetic intensity was different between group B and group C:0.1 mT for group B and 0.6 mT for group C. After 8 weeks,all the animals were killed. Changes of BMD and histomorphometric properties were observed.
Results: Compared with group A,the BMD of whole body,femur and vertebrae of rats in group B increased significantly;the area percentage,number and width of bone trabeculae in vertebrae and femur of rats in group B were larger than those of group A;but the resolution of bone trabeculae of rats in group B was lower than that of group A. The trabecular number in group C rats were significantly decreased,compared with that in group A rats. The outcome of double fluorescence labeling in group B was found to be significantly different with that in group A. But the difference between rats in group A and C was not significant.
Conclusion: This study demonstrates that 50 Hz 0.1 mT SEMFs can increase BMD,improve bone tissue microstructure and,promote bone formation. |
| KEYWORDS:Electromagnetic fields Bone density Bone and bones Rats |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 高玉海,成魁,葛宝丰,甄平,周建,马小妮,李少锋,陈克明.不同强度正弦交变电磁场对大鼠骨密度及骨形态计量学的影响[J].中国骨伤,2014,27(11):933~937 |
| 英文格式: | GAO Yu-hai,CHENG Kui,GE Bao-feng,ZHEN Ping,ZHOU Jian,MA Xiao-ni,LI Shao-feng,CHEN Ke-ming.Effect of different-intensity SEMFs on bone mineral density and histomorphometry in SD rats[J].zhongguo gu shang / China J Orthop Trauma ,2014,27(11):933~937 |
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