| 破骨细胞的骨吸收机制 |
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Received:November 03, 2013
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| 作者 | Author | 单位 | Unit | E-Mail |
| 云帆 |
TI Yun-fan |
南京大学临床医院南京军区南京总医院骨科, 江苏 南京 210002 |
Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China |
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| 王瑞 |
WANG Rui |
南京大学临床医院南京军区南京总医院骨科, 江苏 南京 210002 |
Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China |
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| 赵建宁 |
ZHAO Jian-ning |
南京大学临床医院南京军区南京总医院骨科, 江苏 南京 210002 |
Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China |
zhaojianning.0207@163.com |
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| 期刊信息：《中国骨伤》2014年27卷，第6期，第529-532页 |
| DOI：10.3969/j.issn.1003-0034.2014.06.021 |
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| 破骨细胞是一种巨大的多核细胞，起源于单核巨噬细胞/单核系造血前体细胞，在骨吸收过程中发挥重要作用。破骨细胞的形成和活性异常可导致骨质疏松、类风湿关节炎、关节置换后假体无菌性松动等许多疾病，因此破骨细胞是治疗这些疾病的靶点之一。目前对破骨细胞的分化形成研究较多，但对破骨细胞如何识别、降解骨组织方面的研究较少。骨盐被认为是破骨细胞识别的重要成分，但是近年来的研究发现骨基质不是破骨细胞激活的必需成分，玻连蛋白包被的培养皿也能使破骨细胞出现骨吸收的特有形态，玻连蛋白对破骨细胞的激活有重要的作用。此外，最近的研究证明骨基质降解产物的吞入和分泌对破骨细胞的分化和功能的保持有重要意义。这些分子机制的研究可能为骨骼疾病提供新的治疗靶点。 |
| [关键词]:破骨细胞 吸收 玻连蛋白 综述文献 |
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| Mechanism of osteoclast in bone resorption |
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| Abstract:Osteoclast,a huge coenocytes,originates from mononuclear macrophages or monocytic series hematopoietic precursor cell,plays an important role in the progree of bone resorption. Formation and abnormal activity of osteoclast may cause osteoprosis,rheumatoid arthritis and aseptic loosening after arthroplasty. Therefore,osteoclast is the target for treating these disease. At present,a lot of study on formation of osteoclast were reported,but the study on how to identify and degradation of bone tissue is not yet reported. Bone mineral are seen as important component of identifing osteoclast,and the research suggested that bone matrix is not the essential ingredients of activiting osteoclast,petri dish covered by vitronectin also can make osteoclast occure certain form of bone resorption,vitronectin plays an significant role in activiting osteoclast. Otherwise,the research found that swallowing and secretion of bone matrix degradation products is benefit for differentiation of osteoclast and maintain of function,and this may be therapeutic target for treatment of musculoskeletal disorders. |
| KEYWORDS:Osteoclasts Absorption Vitronectin Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 云帆,王瑞,赵建宁.破骨细胞的骨吸收机制[J].中国骨伤,2014,27(6):529~532 |
| 英文格式: | TI Yun-fan,WANG Rui,ZHAO Jian-ning.Mechanism of osteoclast in bone resorption[J].zhongguo gu shang / China J Orthop Trauma ,2014,27(6):529~532 |
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