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骨髓间充质干细胞治疗脊髓损伤的研究进展

Hits: 2136 Download times: 1157 Received:July 22, 2013

作者	Author	单位	Unit	E-Mail
王郦	WANG Li	浙江医学高等专科学校, 浙江杭州 310053
王倩	WANG Qian	浙江大学医学院, 浙江杭州 310058	Medical College of Zhejiang University, Hangzhou 310053, Zhejiang, China
张晓明	ZHANG Xiao-ming	浙江大学医学院, 浙江杭州 310058	Medical College of Zhejiang University, Hangzhou 310053, Zhejiang, China	zxm@zju.edu.cn

期刊信息：《中国骨伤》2014年27卷，第5期，第437-440页

DOI：10.3969/j.issn.1003-0034.2014.05.021

基金项目:国家自然基金项目：（No. 81272158）

骨髓间充质干细胞以其良好的增殖和多向分化能力，取材方便，易于分离培养和自体移植无免疫源性等特征而成为细胞移植治疗脊髓损伤研究的重点之一。目前已证实蛛网膜下腔注射是最理想的骨髓间充质干细胞治疗途径。早期临床应用骨髓间充质干细胞移植是安全的，对脊髓损伤的修复作用是肯定的，其作用机制可能与骨髓间充质干细胞的替代作用、神经营养作用、抑制免疫反应及促进轴突再生等有关。

[关键词]:骨髓间充质干细胞脊髓损伤干细胞移植

Progress on bone marrow mesenchymal stem cells transplantation for spinal cord injury

Abstract:Bone marrow mesenchymal cells (BMSCs) are regarded as donor cells in cell transplantation therapies for spinal cord injury (SCI) for they have the ability of favourable proliferation and multi-directional differentiation,and are easily isolated and culturd and have less immunological reaction. It has been confirmed that subarachnoid space injection is the most ideal delivery technique of BMSCs. Bone marrow mesenchymal stem cells transplantation is safe and its reconditioning role is certain for SCI in early clinical application. The mechanism of BMSCs promoting functional recovery after SCI is probably concerned with vicarious function,nerve trophism,immunosuppression and promoting axonal regeneration by BMSCs.

KEYWORDS:Bone marrow mesenchymal stem cells Spinal cord injuries Stem cell transplantation

引用本文，请按以下格式著录参考文献：

中文格式:	王郦,王倩,张晓明.骨髓间充质干细胞治疗脊髓损伤的研究进展[J].中国骨伤,2014,27(5):437~440
英文格式:	WANG Li,WANG Qian,ZHANG Xiao-ming.Progress on bone marrow mesenchymal stem cells transplantation for spinal cord injury[J].zhongguo gu shang / China J Orthop Trauma ,2014,27(5):437~440

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