| Hedgehog信号通路与骨质疏松症 |
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Received:June 30, 2013
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| 作者 | Author | 单位 | Unit | E-Mail |
| 罗明 |
LUO Ming |
广州中医药大学附属骨伤科医院骨科, 广东 广州 510240 |
Department of Orthopaedics, Orthopaedics and Traumatology Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510240, Guangdong, China |
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| 黄宏兴 |
HUANG Hong-xing |
广州中医药大学附属骨伤科医院骨科, 广东 广州 510240 |
Department of Orthopaedics, Orthopaedics and Traumatology Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510240, Guangdong, China |
gzhhx@126.com |
| 黄红 |
HUANG Hong |
广州中医药大学附属骨伤科医院骨科, 广东 广州 510240 |
Department of Orthopaedics, Orthopaedics and Traumatology Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510240, Guangdong, China |
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| 李泽钿 |
LI Ze-tian |
广州中医药大学附属骨伤科医院骨科, 广东 广州 510240 |
Department of Orthopaedics, Orthopaedics and Traumatology Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510240, Guangdong, China |
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| 赖圆圆 |
LAI Yuan-yuan |
广州中医药大学附属骨伤科医院骨科, 广东 广州 510240 |
Department of Orthopaedics, Orthopaedics and Traumatology Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510240, Guangdong, China |
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| 期刊信息：《中国骨伤》2014年27卷，第2期，第169-172页 |
| DOI：10.3969/j.issn.1003-0034.2014.02.020 |
| 基金项目:国家自然科学基金（编号：81373653，81302991） |
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| Hedgehog信号通路是一条保守而重要的信号通路，涉及到多种细胞的增殖和分化活动. 近年研究发现，Hedgehog信号通路可以通过上调Runx2和Osx等主要转录因子的表达促进间充质干细胞（mesenchymal stem cells，MSCs）向成骨细胞分化，并且抑制MSCs向脂肪细胞分化. Hedgehog信号通路还可以通过调节细胞周期蛋白促进成骨细胞增殖. 本文综述总结了Hedgehog信号通路调节成骨细胞增殖分化的作用机制，认为Hedgehog信号通路通过促进成骨细胞增殖分化参与调节骨代谢，为骨质疏松症的治疗提供一种新思路. |
| [关键词]:Hedgehog信号通路 成骨分化 骨质疏松症 |
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| Hedgehog signaling pathway and osteoporosis |
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| Abstract:Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and differentiation of many types of cells. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast differentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte. Hedgehog signaling pathway may also promote osteoblast proliferation by regulating cyclin. This review summarizes the mechanism that Hedgehog signaling pathway regulates osteoblast differentiation and proliferation,and concludes that Hedgehog signaling pathway can regulate bone metabolism. It might provide new ideas for the treatment of osteoporosis. |
| KEYWORDS:Hedgehog signaling pathway Osteoblast differentiation Osteoporosis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 罗明,黄宏兴,黄红,李泽钿,赖圆圆.Hedgehog信号通路与骨质疏松症[J].中国骨伤,2014,27(2):169~172 |
| 英文格式: | LUO Ming,HUANG Hong-xing,HUANG Hong,LI Ze-tian,LAI Yuan-yuan.Hedgehog signaling pathway and osteoporosis[J].zhongguo gu shang / China J Orthop Trauma ,2014,27(2):169~172 |
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