| 磨损微粒诱导细胞凋亡与无菌性松动的研究进展 |
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Received:February 25, 2013
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| 作者 | Author | 单位 | Unit | E-Mail |
| 刘国印 |
LIU Guo-yin |
南京大学临床医院 南京军区南京总医院骨科, 江苏 南京 210002 |
Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China |
njwr@163.com |
| 赵建宁 |
ZHAO Jian-ning |
南京大学临床医院 南京军区南京总医院骨科, 江苏 南京 210002 |
Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China |
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| 王瑞 |
WANG Rui |
南京大学临床医院 南京军区南京总医院骨科, 江苏 南京 210002 |
Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China |
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| 期刊信息：《中国骨伤》2013年26卷，第9期，第791-796页 |
| DOI：10.3969/j.issn.1003-0034.2013.09.023 |
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| 无菌性松动是关节置换术后最常见的远期并发症之一,限制了关节假体的使用寿命.近年来人们对假体周围界膜组织内的巨噬细胞、成骨细胞、破骨细胞及成纤维细胞作了大量的研究发现,人工关节置换产生的磨损颗粒在与界膜组织周围的细胞接触或被吞噬后可诱导假体周围界膜的慢性炎症反应并引起细胞凋亡,最终导致假体周围骨溶解以及无菌性松动的发生,提示细胞凋亡在无菌性松动中起着重要作用,细胞凋亡有可能成为无菌性松动新的治疗方法.本文就磨损颗粒引起细胞凋亡与无菌松动之间关系做一综述. |
| [关键词]:巨噬细胞 成骨细胞 破骨细胞 成纤维细胞 细胞凋亡 |
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| Progress on the relationship between wear debris-induced apoptosis and aseptic loosening of prosthesis |
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| Abstract:Aseptic looseningis is one of the most frequent long-term complications after joint replacement,which limits the service lire of prosthesis.A lot of studies have been focused on macrophage,osteoblast,osteoclast and fibroblast in interface membranes around prostheses recently.Aseptic loosening of orthopedic implants used in joint replacement results from bone loss that occurs through the resorptive activity of inflammatory cells activated by the presence of wear particles.Apoptosis has been observed in the periprosthetic site and it has been interpreted as a sign of resolution of inflammation suggesting that apopt osis-related events are indeed associated with periprosthetic osteolysis,targeting the Apoptosis pathway may lead to novel therapeutic approaches for the treatment of aseptic prosthesis loosening.In this thes is,the relationship between wear debris-induced apoptosis and aseptic loosening of prostheses are expoun ded in detail. |
| KEYWORDS:Macrophage Osteoblasts Osteoclast Fibroblasts Apoptosis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 刘国印,赵建宁,王瑞.磨损微粒诱导细胞凋亡与无菌性松动的研究进展[J].中国骨伤,2013,26(9):791~796 |
| 英文格式: | LIU Guo-yin,ZHAO Jian-ning,WANG Rui.Progress on the relationship between wear debris-induced apoptosis and aseptic loosening of prosthesis[J].zhongguo gu shang / China J Orthop Trauma ,2013,26(9):791~796 |
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