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神经营养素在椎间盘源性腰痛机制中的作用

Hits: 2227 Download times: 431 Received:November 16, 2011

作者	Author	单位	Unit	E-Mail
贾治伟	JIA Zhi-wei	海军总医院骨科, 北京 100048
张宝库	ZHANG Bao-ku	海军92196部队, 山东青岛 266011
阮狄克	RUAN Di-ke	海军总医院骨科, 北京 100048		ruandike@yahoo.com.cn

期刊信息：《中国骨伤》2012年25卷，第8期，第698-700页

DOI：10.3969/j.issn.1003-0034.2012.08.023

椎间盘源性腰痛是慢性腰痛常见的类型,然而,其疼痛机制尚不明确。越来越多的证据表明,神经营养素在椎间盘源性腰痛机制中具有重要地位。本文从神经营养素在椎间盘、脊根神经节和脊髓后角等疼痛传递通路中的作用,对其在椎间盘源性腰痛机制中的研究进展进行综述。通过调控神经营养素及其受体来改变疼痛信息传递,为椎间盘源性腰痛的治疗提供新思路。

[关键词]:神经营养素椎间盘腰痛综述文献

Reasearch on mechanism of neurotrophins in discogenic low back pain

Abstract:Discogenic low back pain is the common type of chronic low back pain. However,its mechanism has not been completely clarified. Considerable evidence shows that neurotrophins play an important role in discogenic low back pain. The paper summarizes the mechanism of neurotrophins on discogenic low back pain according to the pain transfer pathway of neurotrophins in intervertebral disc,dorsal horn ganglia and spinal trigeminal nucleus. Changing the pain transmission by regulating neurotrophins and its receptor will provide a new way for the treatment of discogenic low back pain.

KEYWORDS:Neurotrophins Intervertevral disk Low back pain Review literature

引用本文，请按以下格式著录参考文献：

中文格式:	贾治伟,张宝库,阮狄克.神经营养素在椎间盘源性腰痛机制中的作用[J].中国骨伤,2012,25(8):698~700
英文格式:	JIA Zhi-wei,ZHANG Bao-ku,RUAN Di-ke.Reasearch on mechanism of neurotrophins in discogenic low back pain[J].zhongguo gu shang / China J Orthop Trauma ,2012,25(8):698~700

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