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力学刺激对软骨细胞整合素亚单位的调控

Hits: 2475 Download times: 1388 Received:June 18, 2010

作者	Author	单位	Unit	E-Mail
朱鸿飞	ZHU Hong-fei	上海中医药大学康复医学院，上海 201203	Acupuncture and Manipulation College Affiliated to Shanghai University of TCM,Shanghai 201203,China
刘益杰	LIU Yi-jie	上海中医药大学康复医学院，上海 201203	Acupuncture and Manipulation College Affiliated to Shanghai University of TCM,Shanghai 201203,China
褚立希	CHU Li-xi	上海中医药大学康复医学院，上海 201203	Acupuncture and Manipulation College Affiliated to Shanghai University of TCM,Shanghai 201203,China	chulixi2@126.com
冯伟	FENG Wei	上海中医药大学康复医学院，上海 201203	Acupuncture and Manipulation College Affiliated to Shanghai University of TCM,Shanghai 201203,China	fengweifw@yahoo.com.cn

期刊信息：《中国骨伤》2011年24卷，第3期，第266-268页

DOI：10.3969/j.issn.1003-0034.2011.03.027

基金项目:1.上海市卫生局中医药科研基金(编号：2008L043A);2.上海高校创新团队(第二期)建设项目(沪教委科[2009]26号文件);3. 上海市自然科学基金(编号：09ZR432000);4. 上海市浦江人才计划(编号：109J1409300)

骨关节炎(osteoarthritis,OA)是以关节软骨退变、关节缘骨质增生为主要改变的疾病。机械应力可以调节细胞的多种功能，而整合素作为细胞表面应力受体之一，主要介导细胞与细胞外基质(extracellular matrix,ECM)间的黏附，在传导力学信号从而调节细胞的生理功能方面起着重要作用。因此，在软骨病变早中期选择适当的良性刺激(如推拿手法)作用于软骨，调控整合素的表达影响软骨细胞的功能，修复损伤的软骨细胞，延缓关节软骨退变，这对于骨关节炎的治疗有重要意义。

[关键词]:骨关节炎软骨细胞力学整合素类综述文献

Effects of mechanical stimulation on expession of integrin subunits in chondrocyte

Abstract:Osteoarthritis(OA) is a kind of degenerative disease characterized by hyperosteogeny at the joint margins and articular cartilage degeneration. Mechanical stress can regulate the multiple functions of cells. The integrin as one of the mechanoreceptors on the surface of cells,mainly mediated adhesion between cells and extracellular matrix,which plays an important role in the mechanical signal transmission to regulate the physiological functions of cell . Therefore,it is very important to select proper mechanical stimulation(such as naprapathy) in the early and middle stage of osteoarthritis,which regulate the expression of integrins to affect the function of chondrocytes,repair the damaged chondrocyte and delay the articular cartilage degeneration.

KEYWORDS:Osteoarthritis Chondrocytes Mechanics Integrins Review literature

引用本文，请按以下格式著录参考文献：

中文格式:	朱鸿飞,刘益杰,褚立希,冯伟.力学刺激对软骨细胞整合素亚单位的调控[J].中国骨伤,2011,24(3):266~268
英文格式:	ZHU Hong-fei,LIU Yi-jie,CHU Li-xi,FENG Wei.Effects of mechanical stimulation on expession of integrin subunits in chondrocyte[J].zhongguo gu shang / China J Orthop Trauma ,2011,24(3):266~268

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