| 纳米磷酸钙陶瓷人工骨的临床应用研究 |
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Received:May 22, 2009
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| 期刊信息：《中国骨伤》2009年22卷，第11期，第819-821页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的：探讨纳米磷酸钙陶瓷人工骨移植治疗骨缺损的安全性和临床效果。
方法：2005年3月至2007年11月应用纳米陶瓷人工骨治疗四肢骨缺损病例32例(人工骨组),男19例，女13例；年龄17～63岁，平均31.4岁。同期骨折内固定患者36例(内固定组),男21例，女15例；年龄16～65岁，平均32.6岁。两组患者于术后第1、2周及第1、3、6个月检测外周静脉血中Ca、P、B-ALP、IgG 、IgA、IgM、CIC、C3、SL-2R及CD4+/CD8+的比值。并随访用Enneking标准评价肢体功能。
结果：两组患者伤口术后均顺利愈合，各项免疫学检查无明显差异(P>0.05),均未引起血清中钙和磷的明显增高，术后两组B-ALP均升高，3～6个月后内固定组恢复至正常水平，人工骨组仍维持较高水平。随访9～24个月，平均15个月，两组患者均获得了较好的肢体功能，Enneking评价无明显差异(P>0.05).
结论：所用纳米陶瓷人工骨无免疫原性，未引起排斥反应，不影响血液中钙、磷水平，并有一定的成骨活性，临床用以修复腔隙性骨缺损效果肯定。 |
| [关键词]:骨折,不愈合 骨移植 骨代用品 外科手术 |
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| Clinical study of nanmeter calcium phosphate ceramic artificial bone |
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Abstract:
Objective: To study the clinical effects and security of nanometer ceramics artificial bone transplantation to treat the bone defect.
Methods: From March 2005 to November 2007,32 patients(artificial bone group) with extremity bone defects applied nanometer ceramics artificial bone transplantations,included 19 males and 13 females,aged from 17 to 63 years old (averaged 31.4 years). The other 36 patients (internal fixation group) with extremity bone defects were treated by the internal fixation in the same period,included 21 males and 15 females,aged from 16 to 65 years old(averaged 32.6 years). Ca,P,B-ALP,IgG,IgA,IgM,CIC,C3,SL-2R and CD4+/CD8+ in the peripheral venous blood were measured in the 1st and 2th week and 1st,3th,6th month after operation. All patients were followed up and the limb function was evaluated according to Enneking standard.
Results: The wounds of all patients smoothly healed after operation. Every immunological indicators had no significant difference between two groups. Serum calcium and phosphorus content did not significantly increased. Serum B-ALP of all patients were increased after operation,fell to normal levels in the internal fixation group,but remained at a relatively high level in the artificial bone group. All patients were followed-up for from 9 to 24 months (averaged 15 months). All patients get the excellent physical function.
Conclusion: The artificial bone has no immunogenicity,no rejection,does not affect the blood calcium and phosphorus content,and has higher osteogenic activity. It is affirmed that nanometer ceramics artificial bone is used to treat the smaller bone defect on clinical. |
| KEYWORDS:Fractures,ununited Bone transplantation Bone substitutes Surgical procedures,operative |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 孙勇,肖建德,熊建义,刘健全.纳米磷酸钙陶瓷人工骨的临床应用研究[J].中国骨伤,2009,22(11):819~821 |
| 英文格式: | SUN Yong,XIAO Jian-de,XIONG Jian-yi,LIU Jian-quan.Clinical study of nanmeter calcium phosphate ceramic artificial bone[J].zhongguo gu shang / China J Orthop Trauma ,2009,22(11):819~821 |
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