| 恒磁场对SD大鼠深创面愈合的影响 |
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Received:December 25, 2008
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| 作者 | Author | 单位 | Unit | E-Mail |
| 沈建国 |
SHEN Jian-guo |
浙江中医药大学附属第二医院骨科,浙江 杭州 310005 |
Department of Orthopaedics,the Second Hospital of Zhejiang Chinese Medical University, Hangzhou 310005,Zhejiang,China |
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| 陈维善 |
CHEN Wei-shan |
浙江大学附属第二医院骨科 |
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| 王昌兴 |
WANG Chang-xing |
浙江中医药大学附属第二医院骨科,浙江 杭州 310005 |
Department of Orthopaedics,the Second Hospital of Zhejiang Chinese Medical University, Hangzhou 310005,Zhejiang,China |
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| 姜滔 |
JIANG Tao |
浙江中医药大学附属第二医院骨科,浙江 杭州 310005 |
Department of Orthopaedics,the Second Hospital of Zhejiang Chinese Medical University, Hangzhou 310005,Zhejiang,China |
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| 董黎强 |
DONG Li-qiang |
浙江中医药大学附属第二医院骨科,浙江 杭州 310005 |
Department of Orthopaedics,the Second Hospital of Zhejiang Chinese Medical University, Hangzhou 310005,Zhejiang,China |
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| 期刊信息：《中国骨伤》2009年22卷，第5期，第371-374页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的：探讨恒磁场对SD大鼠深创面愈合的影响，恒磁场对创面愈合过程中VEGF表达的影响，以及不同强度恒磁场治疗SD大鼠深创面的区别。
方法：将48只清洁级SD大鼠随机分成0.16 T、0.32 T磁疗组和对照组。分别在术后第3、6、9、12天每组处死4只大鼠，测定创面愈合指数，免疫组化检测肉芽组织VEGF表达。比较各组的创面愈合指数及VEGF表达情况。
结果：①愈合指数。0.16 T磁疗组在第6、9天时的愈合指数高于对照组，差异有统计学意义；0.32 T磁疗组在第3、6、9、12天时的愈合指数高于对照组，差异有统计学意义。0.32 T磁疗组与0.16 T磁疗组相比差异无统计学意义。②创面修复不同时期VEGF表达观察结果。在术后第3、6天磁疗组VEGF表达强于对照组，差异有统计学意义；第9、12天磁疗组与对照组相比差异无统计学意义(P>0.05).0.32 T磁疗组与0.16 T磁疗组相比差异无统计学意义。两个磁疗组在第6天时VEGF阳性率达到整个愈合过程中的峰值，而对照组在第9天时才达到高峰，且VEGF表达强度低于两个磁疗组。
结论：0.16 T及0.32 T恒磁片均能促进SD大鼠深创面的愈合，恒磁场促进深创面愈合的机制可能和在创面愈合早、中期增强VEGF的表达有关。 |
| [关键词]:恒磁场 创面 血管内皮生长因子 |
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| Effect of static magnetic field on deep wound healing of SD rats |
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Abstract:
Objective: To investigate the effect of static magnetic field on deep wound healing of SD rats and VEGF during the wound healing and different strength static magnetic field on deep wound healing of SD rats.
Methods: Divided forty-eight SD rats into three groups:0.16 T magnetic disk treatment (0.16 T group),0.32 T magnetic disk treatment (0.32 T group),control group. General wounds healing situation was observated on the 3,6,9,12 day. The area of every wound was calculated. The tissue of granulation was dyeing by immune tissue chemical decoration method,in which VEGF protein content with its range in tissue was measured.
Results: The healing index of 0.16 T magnetic group wounds were larger than that of control group on 6th and 9th day,there were statistical difference. The healing index of 0.32 T magnetic group wounds were larger than that of control group on 3rd,6th,9th and 12th day,there were statistical difference. The healing index of 0.32 T group wounds contrasted to that of 0.16 T group wounds had no statistical significance. Observation of VEGF at the course of wound healing:the expressing of VEGF in magnetic group wounds on 3rd and 6th was stronger than in control group wounds,there were statistical difference. While there were no obvious difference between them on 9th and 12th day(P>0.05). But the contrast between that in 0.32 T group and in 0.16 T group had no statistical difference. The expressing strength of VEGF in magnetic group reached the peak amplitude on the 6th day,and that in control group reached peak amplitude on 9th day. And the peak amplitude of magnetic group was stronger than that of control group.
Conclusion: Static magnetic disc of 0.16T and 0.32 T can promote deep wound of SD rats heal. The mechanism of static magnetic field promoting wound heal may be relative to the expressing highly of VEGF during early and middle time. |
| KEYWORDS:Static magnetic field Raw surface Vascular endothelial growth factor |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 沈建国,陈维善,王昌兴,姜滔,董黎强.恒磁场对SD大鼠深创面愈合的影响[J].中国骨伤,2009,22(5):371~374 |
| 英文格式: | SHEN Jian-guo,CHEN Wei-shan,WANG Chang-xing,JIANG Tao,DONG Li-qiang.Effect of static magnetic field on deep wound healing of SD rats[J].zhongguo gu shang / China J Orthop Trauma ,2009,22(5):371~374 |
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