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应力状态下软骨基质分解代谢的变化

Hits: 2662 Download times: 1822 Received:June 25, 2008

作者	Author	单位	Unit	E-Mail
邵越峰	SHAO Yue-feng	山西医科大学第二医院骨科,山西太原 030001	Department of Orthopaedics,the Second Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,Shanxi,China
卫小春	WEI Xiao-chun	山西医科大学第二医院骨科,山西太原 030001	Department of Orthopaedics,the Second Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,Shanxi,China	weixiaochun06@yahoo.com.cn

期刊信息：《中国骨伤》2009年22卷，第3期，第241-244页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

基金项目:山西省归国留学人员重点科研项目“软骨细胞的生物力学研究”(编号：200605)

骨关节炎(osteoarthritis,OA)是力学和生物学因素共同作用下导致软骨细胞、细胞外基质以及软骨下骨三者降解和合成正常偶联失衡的结果。OA发病过程中生物力学因素的异常，导致MMPs/TIMPs的失衡，是OA发病的中心环节。因此本文就应力状态下软骨基质分解代谢的变化作一综述。

[关键词]:骨关节炎应力,物理软骨分解代谢

Change of cartilage matrix metabolism under stress

Abstract:With the effects of the mechanics and biological factors,the imbalance between the degradation and synthesis of chondrocyte,extracelluar matrix and subchondral bone leads to the osteoarthritis. The imbalance between MMPs and TIMPs caused by biomechanical abnormality is the key factor of osteoarthritis. This review will focus on the stress and their roles in the metabolism of the cartilage matrix.

KEYWORDS:Osteoarthritis Stress,mechanical Cartilage Metabolism

引用本文，请按以下格式著录参考文献：

中文格式:	邵越峰,卫小春.应力状态下软骨基质分解代谢的变化[J].中国骨伤,2009,22(3):241~244
英文格式:	SHAO Yue-feng,WEI Xiao-chun.Change of cartilage matrix metabolism under stress[J].zhongguo gu shang / China J Orthop Trauma ,2009,22(3):241~244

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