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金属蛋白酶在骨关节炎软骨内环境中的表达与调控

Hits: 2132 Download times: 1317 Received:July 25, 2008

作者	Author	单位	Unit	E-Mail
董刚	DONG Gang	浙江中医药大学第一临床医学院,浙江杭州 310053	The First Clinical Medical College of Zhejiang Chinese Medicine University,Hangzhou 310053,Zhejiang,China
周辉	ZHOU Hui	杭州市中医院骨科

期刊信息：《中国骨伤》2009年22卷，第2期，第156-159页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

关节软骨降解是骨关节炎(OA)的一个重要特征，而金属蛋白酶(MMPs)则是参与OA软骨细胞外基质降解的主要酶系，近年来随着对MMPs激活、活性调节以及相关信号转导通路与转录因子领域的深入研究，其在OA软骨降解中的作用机制逐渐明确，本文从OA软骨中MMPs的激活、表达、调控几个层面上对近几年MMPs与OA软骨相关的理论和实验研究成果进行了综述。

[关键词]:基质金属蛋白酶类骨关节炎软骨

Expression and regulation of matrix metalloproteases in osteoarthritic cartilage

Abstract:The degradation of arthrodial cartilage is a typical characteristic in the pathogenesis of osteoarthritis. matrix metalloproteinases(MMPs) are the primary enzymes involved in extracellular matrix degradation of cartilage. The mechanism of MMPs in extracellular matrix degradation of cartilage is becoming clear with the in-depth study about MMPs,such as activation,activity regulation,related signal transduction pathways and transcription factors. This artice reviewed the activation,expression and regulation of MMPs in the related theory and empirical study of osteoarthritis cartilage.

KEYWORDS:Matrix metalloproteinases Osteoarthritis Cartilage

引用本文，请按以下格式著录参考文献：

中文格式:	董刚,周辉.金属蛋白酶在骨关节炎软骨内环境中的表达与调控[J].中国骨伤,2009,22(2):156~159
英文格式:	DONG Gang,ZHOU Hui.Expression and regulation of matrix metalloproteases in osteoarthritic cartilage[J].zhongguo gu shang / China J Orthop Trauma ,2009,22(2):156~159

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