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骨组织工程研究进展

Hits: 2234 Download times: 1540 Received:June 25, 2008

作者	Author	单位	Unit	E-Mail
李娟	LI Juan	复旦大学附属中山医院骨科，上海 200032	Department of Orthopaedic Surgery,Zhongshan Hospital of Fudan University,Shanghai 200032,China
戴文达	DAI Wen-da	复旦大学附属中山医院骨科，上海 200032	Department of Orthopaedic Surgery,Zhongshan Hospital of Fudan University,Shanghai 200032,China
董健	DONG Jian	复旦大学附属中山医院骨科，上海 200032	Department of Orthopaedic Surgery,Zhongshan Hospital of Fudan University,Shanghai 200032,China

期刊信息：《中国骨伤》2008年21卷，第11期，第880-882页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

组织工程学是应用生命科学和工程学的原理及技术，构建、培育活组织，研制生物替代物，以修复或重建组织器官的结构，维持或改善功能的一门新兴学科。目前组织工程学研究的主要问题是：①种子细胞的体内、体外培养；②支架材料的研究与开发；③种子细胞与基质材料相互作用的调控等。骨创伤、肿瘤和炎症等导致的骨缺损是目前骨科临床的常见病和难治病，惟一的方法是通过骨移植进行修复。利用骨组织工程培养的人工骨不仅可修复大面积的骨缺损，而且可按需塑形及大量制备，是一种理想的创伤修复及功能重建的材料。

[关键词]:骨组织工程细胞骨架综述文献

Progresses in bone tissue engineering

Abstract:Bone tissure engineering plays an important role in tissure engineering. It typically uses an osteoblasts,artificial extracellular matrix(scaffold),and osteoinductive factors which promote cell attachment,differentiation,and mineralized bone formation. So it contents three problems at least:osteoblasts culture in vivo and in vitro,scaffold studies and regulation factors. Bone defect caused by trauma,tumor and inflammation is a frequent and formidable problem in clinical orthopedics. It appears that artificial bone produced by bone tissure engineering can save the problem well. With the development of tissue engineering,bone tissue engineering is developing rapidly. However,seldom experiments are on human body,and fewer productions of bone tissure engineering are used in clinic.

KEYWORDS:Bones Tissure engineering Cytoskeleton Review literature

引用本文，请按以下格式著录参考文献：

中文格式:	李娟,戴文达,董健.骨组织工程研究进展[J].中国骨伤,2008,21(11):880~882
英文格式:	LI Juan,DAI Wen-da,DONG Jian.Progresses in bone tissue engineering[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(11):880~882

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