| 正骨散对实验性损伤局部软组织炎性细胞的影响 |
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Received:June 24, 2008
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| 期刊信息：《中国骨伤》2008年21卷，第10期，第774-775页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:北京市优秀人才培养专项经费资助项目(编号：200301) |
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目的：探讨正骨散在细胞水平对急性软组织损伤的修复机制。
方法：40只新西兰大耳白兔，采用重锤打击法建立急性软组织损伤动物模型，造模后随机分为：正常组(A),模型组(B),赋形剂(凡士林)组(C),正骨散组(D).造模24 h后损伤局部涂药，每日1次，用药4 d后损伤部位取材进行病理组织学观察，Elisa法测定白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子α(TNFα)的含量；放免法测定血栓素(TXB2)和6-酮前列腺素F1α(6-keto-PGF1α)含量。
结果：A组肌组织结构正常，横纹清晰；B组与C组肌纤维肿胀、断裂或明显坏死，间质中度或重度出血、瘀血、水肿和大量炎细胞浸润；D组肌纤维肿胀、间质出血、瘀血、水肿、炎细胞浸润则明显减轻，可见血管和成纤维细胞增生。D组IL-1β、TNFα、TXB2以及TXB2/6-keto-PGF1α比值均明显低于B组和C组；6-keto-PGF1α显着高于B组和C组；各组IL-6无明显变化。
结论：正骨散可促进炎症的吸收与炎性细胞因子的稀释和转运，并能迅速地促进组织的修复与再生，其抗炎镇痛作用与IL-6关系不大。 |
| [关键词]:软组织损伤 中草药 外用药 |
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| Effect of Zhenggu powder(正骨散) on the inflammatory cell factor of soft tissue in experimental acute injury |
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Abstract:
Objective: To probe the recovery mechanism of Zhenggu powder(ZGP) on acute soft tissue injury in cell levels.
Methods: Forty rabbits which established animal model of acute soft tissue injury with hammer hitting,were divided randomly into normal group(A),model group(B),vaseline group(C)and ZGP group(D). Injured part was applied external drug daily after model was made. All animals were killed after using drug for 4 days. The local tissue of injured part was taken pathologic study, and was measured the content of IL-1β， IL-6, TNFα by ELISA method and TXB2,6-keto-PGF1α by RIA method.
Results: Muscular tissue of group A was normal. But that of group B and C was aberrant,such as swelling and broken of muscular fiber or infiltration of inflammatory cell. Such histological change of group D was lightly and hyperplasia of blood vessel was found. The contents of IL-1β，TNFα，TXB2 and TXB2/6-keto-PGF1α in group D were lower than that of group B and group C. On the contrary,the contents of 6-keto-PGF1α in the group D were higher than that of group B and group C. The difference of content of IL-6 between groups was not obvious.
Conclusion: ZGP could promote not only the dilution and the transportation of inflammatory cell factors,but also the repair and the regeneration of the injured tissue structures. The therapeutic effect of ZGP was not relative to IL-6. |
| KEYWORDS:Soft tissue injuries Drugs,Chinese herbal External application drugs |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 齐越峰,卢建秋,赵兴玮,韩静.正骨散对实验性损伤局部软组织炎性细胞的影响[J].中国骨伤,2008,21(10):774~775 |
| 英文格式: | QI Yue-feng,LU Jian-qiu,ZHAO Xing-wei,HAN Jing.Effect of Zhenggu powder(正骨散) on the inflammatory cell factor of soft tissue in experimental acute injury[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(10):774~775 |
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