| 斑蝥黄质对D-半乳糖老龄大鼠骨质影响 |
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Received:September 20, 2007
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| 期刊信息：《中国骨伤》2008年21卷，第8期，第613-616页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的：研究斑蝥黄质对D-半乳糖致衰老大鼠骨质的影响。
方法：将45只6周龄Wistar雄性大鼠随机分为3组(衰老模型组、斑蝥黄质组、青年对照组),每组15只，另设16月龄Wistar雄性大鼠15只作为老龄对照组。其中用D-半乳糖对衰老模型组、斑蝥黄质组大鼠进行连续5个月皮下注射(每日1次，每次20 mg/kg);5个月后连同青年对照组和16月龄老龄对照组一起进行骨常规参数测定并比较组间差异。
结果：衰老模型组骨密度，骨结构力学参数，生物力学参数，骨钙、镁、锰及羟脯氨酸含量均比青年对照组有显着降低(P<0.01),而骨磷含量、骨及血清碱性磷酸转移酶均比青年对照组有显着升高(P<0.01),且这些变化与老龄对照组的变化趋势一致。斑蝥黄质组生物力学参数，骨钙、镁、锰及羟脯氨酸含量，骨磷含量、骨及血清碱性磷酸转移酶等指标均与衰老模型组呈现显着差异(P<0.01).
结论：长期大量摄入D-半乳糖导致大鼠衰老同时可能诱发其发生骨质变化，而斑蝥黄质可以预防或降低此类致老性骨质变化的发生。 |
| [关键词]:骨质疏松 骨密度 羟脯氨酸 斑蝥黄质 |
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| Influence of canthaxanthin on D-galactose induced osseous changes of rat |
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Abstract:
Objective: To study the influence of canthaxanthin on D-galactose induced osseous changes of rat.
Methods: Forty-five six-week-old Wistar male rats were randomly divided into model group,canthaxanthin group and young control group. In addition,15 sixteen-month-old Wistar male rats were used as old control group. Model group and canthaxanthin group were given injections of D-galactose for 5 months(20 mg/kg/once per-day) to cause aging of rat. Then routine osseous parameters were tested and compared among the 4 groups.
Results: Compared with young control group,the BMD,parameters of structural mechanics and biomechanics,bone calcium,manganese,magnesium and the content of hydroxyproline in the model group decreased significantly(P<0.01),however,the content of bone phosphorus,the activity of bone and serum ALP increased significantly (P<0.01). Those changes of the model group were the same as the old control group,but the changes in the canthaxanthin group significantly differed with the model group (P<0.01).
Conclusion: The high does of D-galactose intake can cause aging and osteoporosis at the same time in rat,but canthaxanthin can prevent and inhibit D-galactose induced osseous changes. |
| KEYWORDS:Osteoporosis Bone density Hydroxyproline Canthaxanthin |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 裴凌鹏,惠伯棣,董福慧.斑蝥黄质对D-半乳糖老龄大鼠骨质影响[J].中国骨伤,2008,21(8):613~616 |
| 英文格式: | PEI Ling-peng,HUI Bo-di,DONG Fu-hui.Influence of canthaxanthin on D-galactose induced osseous changes of rat[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(8):613~616 |
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