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双膦酸盐在骨转移瘤中的应用进展

Hits: 1938 Download times: 1350 Received:July 04, 2007

作者	Author	单位	Unit	E-Mail
梁鹏	LIANG Peng	甘肃省肿瘤医院骨科，甘肃兰州 730050	Department of Orthopaedics,the Gansu Cancer Hospital,Lanzhou 730050,Gansu,China	liangplz0801@hotmail.com

期刊信息：《中国骨伤》2008年21卷，第6期，第480-482页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

骨转移瘤是肿瘤患者的严重并发症，与骨痛、病理性骨折、神经缺失和(或)高钙血症等紧密相关，因此，骨转移瘤的治疗是必要的。双膦酸盐是标准的治疗和预防骨相关事件的药物，可抑制破骨细胞介导的骨吸收，显示抗癌活性，是最有效的治疗骨转移瘤和预防骨转移并发症的药物，可降低患者骨相关事件的发生，提高患者生活质量。

[关键词]:骨肿瘤肿瘤转移二膦酸盐类综述文献

The application advances of Bisphosphonates in bone metastasis

Abstract:Bone metastases is a serious complication of patients with tumor. It is associated with substantial morbidity,including bone pain,pathological fracture,neurological deficit and(or) hypercalcemia. Thus,the management of bone metastasis is a clinically significant issue. Bisphosphonates have now become a part of standard therapy to treat and prevent skeletal-related events(SRE),it could inhibit osteoclast-mediated bone resorption and demonstrate antitumor activity in preclinical models. Bisphosphonates are the most effective agent for treating and(or) preventing complications of bone metastasis,reducing the incidence of skeletal-related events,and improving quality of life in patients with bone metastasis.

KEYWORDS:Bone neoplasms Neoplasm metastasis Diphosphonates Review literature

引用本文，请按以下格式著录参考文献：

中文格式:	梁鹏.双膦酸盐在骨转移瘤中的应用进展[J].中国骨伤,2008,21(6):480~482
英文格式:	LIANG Peng.The application advances of Bisphosphonates in bone metastasis[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(6):480~482

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