| 悬吊模拟失重及解悬吊对大鼠骨密度及生物力学的影响 |
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Received:October 30, 2007
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| 作者 | Author | 单位 | Unit | E-Mail |
| 佟海英 |
TONG Hai-ying |
北京中医药大学基础医学院中药教研室，北京 100029 |
Laboratory of the TCM,Preclinical Medical College of Beijing University of TCM,Beijing 100029,China |
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| 胡素敏 |
HU Su-min |
北京中医药大学基础医学院中药教研室，北京 100029 |
Laboratory of the TCM,Preclinical Medical College of Beijing University of TCM,Beijing 100029,China |
cinndyhu@yahoo.com.cn |
| 周鹏 |
ZHOU Peng |
北京中医药大学基础医学院中药教研室，北京 100029 |
Laboratory of the TCM,Preclinical Medical College of Beijing University of TCM,Beijing 100029,China |
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| 傅骞 |
FU Qian |
北京中医药大学基础医学院中药教研室，北京 100029 |
Laboratory of the TCM,Preclinical Medical College of Beijing University of TCM,Beijing 100029,China |
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| 李谨 |
LI Jin |
北京积水潭医院放射科骨密度室 |
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| 高学敏 |
GAO Xue-min |
北京中医药大学基础医学院中药教研室，北京 100029 |
Laboratory of the TCM,Preclinical Medical College of Beijing University of TCM,Beijing 100029,China |
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| 张建军 |
ZHANG Jian-jun |
北京中医药大学基础医学院中药教研室，北京 100029 |
Laboratory of the TCM,Preclinical Medical College of Beijing University of TCM,Beijing 100029,China |
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| 期刊信息：《中国骨伤》2008年21卷，第4期，第276-279页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:1.国家自然科学基金(编号：30500663);2.国家基础科学人才培养基金科研训练项目(编号：20070110) |
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目的：观察尾部悬吊模拟失重及解悬吊后大鼠骨密度及生物力学的变化。
方法：20只Wistar雄性大鼠随机分成空白组和模型组。模型组尾部悬吊14 d,解悬吊后继续饲养14 d,空白组则正常饲养28 d.实验第14 天活体检测各组大鼠颅骨、T2椎体、L4椎体、骨盆、右侧桡尺骨和右侧股骨的骨密度(bone mineral density,BMD);实验第28 天处死大鼠，检测右侧股骨及L4椎体 BMD 及生物力学强度。
结果：与空白组相比，实验第14 天，模型组大鼠股骨、骨盆、腰椎 BMD 明显低，差异有统计学意义(P<0.001,P<0.001,P<0.01);颅骨、胸椎、桡尺骨 BMD 无明显变化(P>0.05).实验第28 天，模型组大鼠股骨、腰椎 BMD 和股骨最大载荷明显低，差异有统计学意义(P<0.01,P<0.001,P<0.01).
结论：大鼠尾部悬吊14 d即可引起骨代谢的紊乱：承重骨骨矿盐大量丢失；即使解悬吊14 d后承重骨 BMD 及力学强度也明显降低，表明骨代谢紊乱短期内不能恢复正常。 |
| [关键词]:骨 骨密度 生物力学 失重模拟 代谢 |
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| Effects on rats' bone mineral density and bone biomechanics by suspensory simulated weightlessness and removing suspension |
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Abstract:
Objective: To study the effects on rats' bone mineral density and bone biomechanics by suspensory simulated weightlessness and removing suspension.
Methods: Twenty Wistar rats were divided into two groups randomly as control group and model group. Suspend the model group rats for 14 days,then remove suspension and continue to feed for another 14 days. Feed control group rats for 28 days. Detect the bone mineral density(BMD)in vivo of cranial bone,second thoracic vertebra,fo- urth lumbar vertebra,pelvis,right radioulna and right femoral bone of each group at the 14th day. At the 28th day,execute all the rats and take out of right femoral bone and fourth lumbar vertebra for detecting BMD and the intensity of biomechanics.
Results: At the 14th day in experiment,being compared with control group,the BMD of femoral bone,pelvis and lumbar vertebra in model group decreased significantly(P<0.001,P<0.001,P<0.01)and the change of BMD of cranial bone,thoracic vertebra a- nd radioulna in model group was not remarkable(P>0.05). At the 28th day in experiment,the BMD of femoral bone and lumbar vertebra,the maximal load of femoral bone decreased significantly in model group as compared with control group(P<0.01,P<0.001,P<0.01).
Conclusion: BMD in vivo body showed that suspensory simulated weightlessness for 14 days could cause disorder of bone metabolism and remarkable mineral loss of weight bearing bone,even BMD and biomechanical intensity of weight bearing bone decrease obviously when removing suspension for 14 days. The results suggest that the disorder of bone metabolism could not be recovered in short time. |
| KEYWORDS:Bones Bone density Biomechanics Weightlessness simulation Metabolism |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 佟海英,胡素敏,周鹏,傅骞,李谨,高学敏,张建军.悬吊模拟失重及解悬吊对大鼠骨密度及生物力学的影响[J].中国骨伤,2008,21(4):276~279 |
| 英文格式: | TONG Hai-ying,HU Su-min,ZHOU Peng,FU Qian,LI Jin,GAO Xue-min,ZHANG Jian-jun.Effects on rats' bone mineral density and bone biomechanics by suspensory simulated weightlessness and removing suspension[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(4):276~279 |
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