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TGF-β促纤维化机制及中药干预的研究进展

Hits: 2048 Download times: 1219 Received:April 22, 2007

作者	Author	单位	Unit	E-Mail
王荣国	WANG Rong-guo	北京中医药大学针灸学院，北京 100029	School of Acupuncture,Moxibustion & Tuina,Beijing University of Chinese Medicine,Beijing 100029,China	wgls2001@163.com
周卫	ZHOU Wei	中国中医科学院望京医院
章永东	ZHANG Yong-dong	中国中医科学院望京医院

期刊信息：《中国骨伤》2008年21卷，第2期，第161-163页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

转化生长因子(TGF-β)是影响伤口愈合与瘢痕形成的重要生物因子，它能促进细胞增殖、迁移、分化和凋亡，同时刺激细胞外基质沉积和胶原过度产生。TGF-β的生物作用受到很多相关因子的调节(核心蛋白聚糖、结缔组织生长因子等).中药治疗纤维化及瘢痕有其独特疗效，在减少瘢痕的同时能加速伤口愈合。越来越多的实验证实单味中药或中药复方能通过减少TGF-β的表达而抑制纤维化，最终减轻瘢痕形成。本文综述了近年来TGF-β调控瘢痕形成的机制和中药通过控制TGF-β的作用而减少纤维化的研究现状。

[关键词]:转化生长因子β 瘢痕纤维化中医药综述文献

Study on the progress of the mechanism of TGF-β in the scarring and the effect of TCM

Abstract:Transforming growth factor(TGF-β)plays a central role in wound healing and scarring. TGF-β is a member of c- ytokine family,involving cell proliferation,migration,differentiation and apoptosis,which subsequently trigger extracellular matrix(ECM)deposite and collagen overproduction. A number of regulators of TGF-β expression have been identified,including Decorin,CTGF,etc. TCM can reduced later scarring,and it accelerates wound healing. TCM can reduce the expression of TGF-β，resistance of fibrosis,so that lighten the development of scar. This article reviewed the mechanism of TGF-β in the scarring and TCM can decrease the development of scar effected by TGF-β。

KEYWORDS:Transforming growth factor beta,TGF-β Cicatix Fibrosis Traditional Chinese medicine Review literature

引用本文，请按以下格式著录参考文献：

中文格式:	王荣国,周卫,章永东.TGF-β促纤维化机制及中药干预的研究进展[J].中国骨伤,2008,21(2):161~163
英文格式:	WANG Rong-guo,ZHOU Wei,ZHANG Yong-dong.Study on the progress of the mechanism of TGF-β in the scarring and the effect of TCM[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(2):161~163

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