| 病证结合中药组方治疗类风湿性关节炎活动期临床对照试验 |
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Received:October 10, 2007
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| 期刊信息：《中国骨伤》2007年20卷，第12期，第826-829页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:国家中医药管理局中医药科学技术研究专项资金(编号:04-05LP45) |
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目的:探讨在中医辨证的基础上,采用现代药理研究证实具有消炎镇痛或免疫抑制作用的中药进行组方,治疗类风湿性关节炎活动期患者,并与西药甲氨喋呤加尼美舒利作对照,观察其疗效和安全性。
方法:选择类风湿性关节炎活动期患者60例,分为试验组30例和对照组30例。试验组采用病证结合方法给予中药煎剂口服,每日1剂;对照组口服甲氨喋呤7.5~10 mg（1次/周）+尼美舒利分散片100 mg（2次/日）,分别在治疗后第8周随访,评价两组临床疗效和不良反应。
结果:治疗8周后2组疾病疗效比较:试验组有效率为81.5%（22/27）,对照组有效率为76.0%（19/25）,两组比较差异无统计学意义（P=0.629>0.05）。两组证候疗效比较:试验组有效率为97.0%（26/27）,对照组有效率为76.0%（19/25）,两组比较差异有统计学意义（P=0.046<0.05）。两组临床观察指标比较,试验组在改善关节肿胀数、双手握力、晨僵时间等方面,疗效优于对照组（P<0.05）;在关节疼痛VAS评分、关节压痛数、关节功能分级等方面与对照组比较差异无统计学意义（P>0.05）。两组实验室指标比较,试验组在降低C反应蛋白方面明显优于对照组（P<0.05）;在降低血沉和类风湿因子方面与对照组比较差异无统计学意义（P>0.05）。两组不良反应比较,其不良事件发生率差异有统计学意义（P<0.05）。
结论:病证结合中药组方治疗类风湿性关节炎与对照组疗效相当;但在改善证候积分、消肿、降低晨僵时间、提高双手握力、降低C反应蛋白等方面明显优于对照组,不良反应明显低于对照组,是值得提倡的治疗类风湿性关节炎活动期的有效方法。 |
| [关键词]:关节炎,类风湿 中医治法 甲氨喋呤片 尼美舒利分散片 临床对照试验 |
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| A controlled clinical trial on active RA treated with recipe of Chinese herbs according to TCM therapeutic methods |
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Abstract:
Objective:To evaluate clinical curative effect and adverse effect of the recipe of Chinese herbs prescripted according to the nature of disease and syndrome differentiation of TCM.
Methods:Sixty patients were divided into 2 groups,there were 30 patients in treatment group treated with the recipe of Chinese herbs and 30 patients in control group treated with MTX and nimesulide dispersible tablets.The clinical curative effect and adverse effect were evaluated at the end of 8 weeks.
Results:Effective powers assessed with disease curative effect standard in both groups showed no statistics difference,P>0.05.There was statistics difference of two groups when effective powers assessed with syndromes of TCM,P<0.05.Adverse reaction in treatment group was less than that in control group(P<0.05).
Conclusion:The recipe of Chinese herbs prescripted according to the nature of disease and syndrome differentiation of TCM have an equivalent effect to MTX plus nimesulide dispersible tablets and with less adverse reaction in treating RA. |
| KEYWORDS:Arthritis,Rheumatoid TCM therapeutic method Methotrexate tablets Nimesulide dispersible tablets Controlled clinical trial |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 申洪波,白云静,胡荫奇,李为农.病证结合中药组方治疗类风湿性关节炎活动期临床对照试验[J].中国骨伤,2007,20(12):826~829 |
| 英文格式: | SHEN Hong-bo,BAI Yun-jing,HU Yin-qi,LI Wei-nong.A controlled clinical trial on active RA treated with recipe of Chinese herbs according to TCM therapeutic methods[J].zhongguo gu shang / China J Orthop Trauma ,2007,20(12):826~829 |
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