| 骨关节炎早期的Ⅱ型胶原代谢产物 |
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Received:January 23, 2007
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| 作者 | Author | 单位 | Unit | E-Mail |
| 班吉鹤 |
BAN Ji-he |
南京大学医学院南京军区总医院骨科,江苏南京210002 |
Department of Orthopaedics,the General Hospital of Nanjing Military Command,the Medical College of Nanjing University,Nanjing 210002,Jiangsu,China |
zhoujuan1009@163.com |
| 赵建宁 |
ZHAO Jian-ning |
南京大学医学院南京军区总医院骨科,江苏南京210002 |
Department of Orthopaedics,the General Hospital of Nanjing Military Command,the Medical College of Nanjing University,Nanjing 210002,Jiangsu,China |
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| 期刊信息：《中国骨伤》2007年20卷，第7期，第500-503页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:江苏省自然科学基金(BK2005085) |
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| 骨关节炎是以关节软骨渐进性破坏为特点的、普遍的致残性疾病。临床上需要一些早期即可以测量的、敏感的、特异性的标志物来诊断疾病。软骨的主要组成是Ⅱ型胶原,所以其合成和降解所产生的生物学标志物已成为研究重点。对关节滑液、血清、尿中的生物学标志物的检测可以早期诊断疾病、监测疾病的发展、了解机体对治疗药物的反应。Ⅱ型胶原合成的产物包括:Ⅱ型胶原C前肽、ⅡA型胶原N前肽。Ⅱ型胶原降解产物包括:Ⅱ型胶原C端肽、Ⅱ型胶原新抗原表位、Ⅱ型螺旋、单克隆抗体C2C结合肽段、可氰溴化的9.7肽段、Ⅱ型胶原-1和硝化的Ⅱ型胶原-1。本文仅对Ⅱ型胶原合成、降解所产生的生物学标志物与早期骨关节炎之间的关系加以阐述。 |
| [关键词]:生物学标记 胶原Ⅱ型 骨关节炎 |
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| Metabolites of type Ⅱcollagen in early osteoarthritis |
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| Abstract:Osteoarthirtis(OA) which is the characterized by progressive destruction of the articular cartilage,is a universal disabling disease.The measurable,sensitive and specific biomarkers,which can be detected in the early stage of disease,are very necessary for the diagnosis in clinics.The primary component of articular cartiage is type Ⅱ collagen (C Ⅱ),so produced in the synthesis and degradation of C Ⅱ are extensively investigatived.Assaying these biomarkers in synovia fluid,serum and urine is useful in early diagnosis,detecting disease development,understanding or ganism response to anti-arthritic drugs.Synthetic biomarkers of C Ⅱ include the type Ⅱ procollagen C-propeotide(P ⅡCP)and the type ⅡA procollagen N-propeptide(P ⅡANP).Degradation products of C Ⅱ include C Ⅱ C-telopeptide (CTX-Ⅱ),C Ⅱ C-terminal neoepitope(TIINE),helix-Ⅱ,monclonal antibody C2C combinded peptide,the cyanogen brominated 9.7,type Ⅱ collogen-1(collogon2-1,coll2-1) and nitrated type Ⅱ collogen-1(nitrated collogon2-1,coll2-1NO2).The article summarizes the relationship between biomarkers of C Ⅱ and early OA. |
| KEYWORDS:Biological markers Collagen typeⅡ Osteoarthritis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 班吉鹤,赵建宁.骨关节炎早期的Ⅱ型胶原代谢产物[J].中国骨伤,2007,20(7):500~503 |
| 英文格式: | BAN Ji-he,ZHAO Jian-ning.Metabolites of type Ⅱcollagen in early osteoarthritis[J].zhongguo gu shang / China J Orthop Trauma ,2007,20(7):500~503 |
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