| 中医骨折分期治疗对骨折愈合作用的X线与组织学研究 |
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Received:February 28, 2006
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| 作者 | Author | 单位 | Unit | E-Mail |
| 温建民 |
WEN Jian-min |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
xuy ingpeng@etang.com |
| 徐颖鹏 |
XU Ying-peng |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
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| 孙永生 |
SUN Yong-sheng |
北京大学第三医院骨科 |
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| 雷仲民 |
LEI Zhong-min |
首都医科大学附属北京中医医院骨科 |
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| 徐海斌 |
WEN Jian-min |
新乡医学院第一附属医院 |
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| 桑志成 |
SANG Zhi-cheng |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
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| 胡海威 |
HU Hai-wei |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
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| 成永忠 |
CHENG Yong-zhong |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
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| 佟云 |
TONG Yun |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
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| 孙卫东 |
SUN Wei-dong |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
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| 韩凤岳 |
HAN Feng-yue |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
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| 李莉 |
LI Li |
中国中医科学院望京医院骨科,北京100102 |
Department of Orthopaedics,Wangjing Hospital of China Academy of Chinese Medicine Sciences,Beijing 100102,China |
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| 期刊信息：《中国骨伤》2006年19卷，第10期，第604-607页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:国家中医药管理局资助项目(编号:04-05JP67) |
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目的:研究中医骨折分期治疗对骨折愈合的作用,探讨中药治疗骨折的最佳分期方法。
方法:于SD大鼠双侧胫骨上1/3段前部的中点,造成2mm×1.5mm骨质缺损,作为骨折愈合模型。222只雄性SD大鼠,首先随机取出6只作为正常对照组,其他216只于造模后随机分为4组:三期治疗组、二期治疗组、一期治疗组以及模型对照组,每组54只。分别给予中药三期、二期、一期治疗以及等量生理盐水治疗。分别于术后1、3、5、7、9、12、15、21、28d每组随机处死6只大鼠,取右侧胫骨标本作为观察对象,通过X线检查及组织学检查评价几种分期治疗方法对骨缺损愈合的作用。
结果:X线片肉眼观察示:模型对照组自术后7d起,各时间点评分均低于或等于用药组,部分时间点差异有显著性统计意义(P<0.05),二期治疗组总平均评分最高,但组间差异无显著性统计意义。X线片图像分析显示:术后9~28d,模型对照组在各个时间点的骨痂填充率均低于各用药组,但差异无显著性统计意义,各中药治疗组骨折愈合较模型对照组提前约1周。二期治疗组平均骨痂填充率最高,但组间差异无显著性统计意义。组织学观察示:模型对照组在术后大部分时间点组织学评分低于各用药组,部分时间点差异有显著性统计意义(P<0.05),二期治疗组在术后5~15d大部分时间点组织学评分有高于一期治疗组和三期治疗组的趋势。二期治疗组平均评分最高,但组间差异无显著性统计意义。
结论:对骨折分期辨证治疗是必要的,二期治疗可能是骨折治疗的最佳分期方法。 |
| [关键词]:骨折 中医疗法 放射学 组织学 |
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| Radiological and histological study on treating fracture with different prescription of TCM in different healing stages |
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Abstract:
Objective:To observe the effects of treating fracture with different prescription of TCM in different healing stages,and to explore the optimal phasing method in treating fracture.
Methods:A 2-mm-wide 1.5-mm-deep defect was bilaterally made as fracture healing model in the middle of the anterior part of the proximal one-third segment of tibia shaft of a SD rat.At first,6 SD rats were taken randomly from 222 male SD rats into the normal control group.Postoperatively,the others were divided randomly into four groups:the model control group,the one-period treatment group,the two-period treatment group and the three-period treatment group on average.The rats in one-period treatment group underwent TCM in 1 period,those in two-period treatment group in 2 periods,those in three-period treatment group in 3 periods,and those in both the model control group and the normal control group were given saline at the same dose.On day 1,3,5,7,9,12,15,21 and 28 after operation,6 rats in each group were selected randomly and sacrificed.Taking their right tibia as the object,the fracture healing was studied through observing and image analyzing of X-ray films and histology observation.
Results:The X-ray observation showed that the score of the model control group were less than or equal to that of all treatment groups since the 7th day after operation.The average score of two-period treatment group was the highest.The image analysis result showed that all treatment groups had a higher callus filling rate (CFR) than that of model control group,and the fracture healing of all treatment groups were promoted for about 1 week.The average CFR of two-period treatment group was the highest.In histological examination,the result also showed that the histological scores of model control group were less than that of all treatment groups in the most time points after operation.From the 5th day to 15th day,the scores of two-period treatment group had the tendency of being higher than that of the one-period treatment and three-period treatment groups.The average score of two-period treatment group was higher than that of other three groups.But it had no significant difference.
Conclusion:Using different prescription of TCM in different stages of fracture healing is necessary.And the two-period treatment may be the optimal way to treat bone fracture. |
| KEYWORDS:Fractures TCM therapy Radiology Histology |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 温建民,徐颖鹏,孙永生,雷仲民,徐海斌,桑志成,胡海威,成永忠,佟云,孙卫东,韩凤岳,李莉.中医骨折分期治疗对骨折愈合作用的X线与组织学研究[J].中国骨伤,2006,19(10):604~607 |
| 英文格式: | WEN Jian-min,XU Ying-peng,SUN Yong-sheng,LEI Zhong-min,WEN Jian-min,SANG Zhi-cheng,HU Hai-wei,CHENG Yong-zhong,TONG Yun,SUN Wei-dong,HAN Feng-yue,LI Li.Radiological and histological study on treating fracture with different prescription of TCM in different healing stages[J].zhongguo gu shang / China J Orthop Trauma ,2006,19(10):604~607 |
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