| 红景天对高原去势大鼠骨质疏松症的血清IL-6、TNF-α和尿DPD影响 |
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Received:October 11, 2005
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| 作者 | Author | 单位 | Unit | E-Mail |
| 白孟海 |
BAI Meng-hai |
兰州军区兰州总医院骨科研究所,甘肃兰州730050 |
Institute of Orthopaedics and Traumatology,Lanzhou General Hospital of PLA,Lanzhou 730050,Gansu,China |
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| 葛宝丰 |
GE Bao-feng |
兰州军区兰州总医院骨科研究所,甘肃兰州730050 |
Institute of Orthopaedics and Traumatology,Lanzhou General Hospital of PLA,Lanzhou 730050,Gansu,China |
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| 刘剑梅 |
LIU Jian-mei |
兰州军区兰州总医院骨科研究所,甘肃兰州730050 |
Institute of Orthopaedics and Traumatology,Lanzhou General Hospital of PLA,Lanzhou 730050,Gansu,China |
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| 王琦 |
WANG Qi |
兰州军区兰州总医院骨科研究所,甘肃兰州730050 |
Institute of Orthopaedics and Traumatology,Lanzhou General Hospital of PLA,Lanzhou 730050,Gansu,China |
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| 高文魁 |
GAO wen-kui |
西宁市解放军第四医院 |
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| 郑荣 |
ZHENG Rong |
兰州军区兰州总医院骨科研究所,甘肃兰州730050 |
Institute of Orthopaedics and Traumatology,Lanzhou General Hospital of PLA,Lanzhou 730050,Gansu,China |
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| 期刊信息：《中国骨伤》2006年19卷，第4期，第221-222页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:全军科研基金课题(编号:01Z008) |
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目的:探讨高原高寒地区低氧环境去势大鼠骨质疏松症与血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和尿脱氧吡啶酚(DPD)的关系及红景天预防骨质疏松的作用。
方法:选用Wistar雌性大白鼠75只,分别摘除卵巢或假性去卵巢。分为A组(假手术组),B组(切除卵巢组),C组(切除卵巢+尼尔雌醇组),D组(切除卵巢+红景天混合饲料组),E组(切除卵巢+红景天浸液组)。每组15只,术后在海拔3100m青海海北州地区饲养,术后3个月处死,应用放免方法测定血清IL-6、TNF-α和化学发光法测定尿中DPD含量。
结果:B组血清IL-6、TNF-α和尿DPD含量显著高于A、C、D、E组。C、D、E组血清IL-6、TNF-α和尿DPD含量与A组比较差异无显著性统计学意义。
结论:红景天的抗高原骨质疏松症的作用可能与降低血清IL-6、TNF-α含量和尿中DPD浓度有关。 |
| [关键词]:骨质疏松,绝经后 动物,实验 白细胞介素-6 肿瘤坏死因子-α 尿脱氧吡啶酚 |
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| Effect of CO-RADIOD(RACC) on the contents of IL-6 and TNF-α in the serum and DPD in the urine of ovariectomized rats with osteoporosis at high altitude |
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Abstract:
Objective:To discuss the relationship between ovariectomized rats with osteoporosis and IL-6,TNF-α in the serum and DPD in the urine at high altitude and the preventive effects of RACC on osteoporosis.
Methods:Seventy-five ovariectomized Wistar female rats were divided into group A(sham operation group),group B(ovariectomized group),group C(ovariectomized+nilestriol),group D(ovariectomized+mixed feed of RACC),group E(ovariectomized+RACC immersion).The contents of IL-6,TNF-α in the serum and DPD in the urine were measured after 3 months of feed in Haibei district of Qinghai(3 100 m above sea level).
Results:The contents of IL-6,TNF-α in the serum and DPD in the urine in group B were significantly highter than those of the group A,C,D and E;the contents of IL-6,TNF-α in the serum and DPD in the urine in the group C,D and E had no significant difference compared with gruop A.
Conclusion:The preventive effect of RACC on osteoporosis may relate to the decrease of contents of IL-6,TNF-α in the serum and DPD in the urine. |
| KEYWORDS:Osteoporosis,postmenopausal Animals,laboratory Interleukin-6 Tumor necrosis factor-α Deoxypyridinoline |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 白孟海,葛宝丰,刘剑梅,王琦,高文魁,郑荣.红景天对高原去势大鼠骨质疏松症的血清IL-6、TNF-α和尿DPD影响[J].中国骨伤,2006,19(4):221~222 |
| 英文格式: | BAI Meng-hai,GE Bao-feng,LIU Jian-mei,WANG Qi,GAO wen-kui,ZHENG Rong.Effect of CO-RADIOD(RACC) on the contents of IL-6 and TNF-α in the serum and DPD in the urine of ovariectomized rats with osteoporosis at high altitude[J].zhongguo gu shang / China J Orthop Trauma ,2006,19(4):221~222 |
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