| 酒精性骨质疏松症的动物模型研究 |
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Received:April 13, 2005
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| 期刊信息：《中国骨伤》2005年18卷，第12期，第735-736页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:福建省教育厅科技项目(编号:JA03122) |
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目的:建立酒精性骨质疏松症的动物模型,研究酒精对骨质疏松的影响。
方法:SD大鼠分为3组:实验组A、实验组B及对照组。实验组A给予45°白酒8 ml.kg-1.d-1,每天2次灌胃,实验组B给予45°白酒6 ml.kg-1.d-1,每天2次灌胃,对照组以等量生理盐水灌胃,分别于8、16、24周后取材检测相关指标。
结果:8周后实验组A尿液中尿吡啶酚(PYD)显著增高(P<0.01);16周后实验组A的BMD显著下降(P<0.01),各实验组的SOD活性较之同期对照组显著下降(Plt;0.05),MDA含量显著增高(Plt;0.05);24周后实验组A的TC、TG、LDL均显著增高(P<0.01),而HDL则显著降低(Plt;0.01)。
结论:大量白酒灌胃,可致大鼠骨质疏松。 |
| [关键词]:酒精中毒 骨质疏松 动物,试验 |
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| Experimental study on the animal model of alcoholic osteoporosis |
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Abstract:
Objective: To produce animal model of alcoholic osteoporesis and to study the effect of alcohol on osteoporesis.
Methods:Sprague-Dawley rats were randomly divided into three groups:test group A（Group A）,test group B（Group B） and control group.45° white wine was fed into stomachs of rats twice a day at doses of 8 ml.kg-1.d-1 and 6 ml.kg-1.d-1 in Group A and B respectively.In control group,the same dose of Sodium Chloride was fed.The specimens were obtained at 8th,16th and 24th weeks after experiment to detect related indices.
Results:At 8th week,the content of PYD in urine of Group A increased significantly（P<0.01）.At 16th week,the content of BMD of Group A decreased significantly （P<0.05）,and the SOD activity of two test groups decreased significantly as compared with control group（P<0.05）,but the content of MDA increased（P<0.05）.At 24th week,the contents of TC,TG and LDL in the serum of Group A increased significantly（P<0.01）,but HDL content decreased significantly（P<0.01）.
Conclusion:Drinking lots of white wine can induce osteoporesis of rats. |
| KEYWORDS:Alcoholism Osteoporosis Animals,laboratory |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 齐振熙,王明千.酒精性骨质疏松症的动物模型研究[J].中国骨伤,2005,18(12):735~736 |
| 英文格式: | QI Zhen-xi,WANG Ming-qian.Experimental study on the animal model of alcoholic osteoporosis[J].zhongguo gu shang / China J Orthop Trauma ,2005,18(12):735~736 |
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