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冻干同种异体骨与冻干异种骨移植治疗骨缺损的比较实验研究

Hits: 2930 Download times: 2124 Received:July 20, 2004

作者	Author	单位	Unit	E-Mail
刘玉增	LIU Yu-zeng	中国人民解放军总医院骨科北京100853	The 301st Hospital of PLA,Beijing,100853,China
李琪文	LI Qi-wen	内蒙古医学院第二附属医院
王继芳	WANG Ji-fang	中国人民解放军总医院骨科北京100853	The 301st Hospital of PLA,Beijing,100853,China

期刊信息：《中国骨伤》2005年18卷，第5期，第282-284页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

目的:对比观察冻干同种异体骨和冻干异种骨骨移植治疗骨缺损的效果。

方法:48只中国大白兔一侧桡骨造成1cm骨缺损,随机分为同种异体骨组和异种骨组,每组24只,分别植入两种移植骨,术后4、8、12周分批取材,进行X线片和组织学检查,然后做对比分析。

结果:术后4周异种骨组的X线片,GaryX线评分与同种异体骨组有统计学差异,而术后8周同种异体骨组组织学检查以及组织学评分与异种骨组有统计学差异,在其他时期两组比较无统计学差异。

结论：冻干异种骨具有很好的成骨效果,可以作为修复骨缺损的移植材料。

[关键词]:冻干同种异体骨冻干异种骨骨移植骨缺损

Experimental comparison of freeze-drying allograft bone with freeze-drying xenograft bone for the repair of segmental bone defect

Abstract:

Objective: To compare the therapeutic effect of repairing bone defect with freeze-drying allograft and xenograft bone.

Methods:Forty-eight rabbits were divided into two groups randomly(allograft group and xenograft group).A segmental bone defect(length 1 cm)was created at one side of radius in each rabbit.The therapeutic effect of segmental bone defect was assessed by serial radiographic and histologic studies respectively.

Results:Xenograft was superior to allograft on X-ray,Gary's radiographic scoring in the fourth week.And allograft was superior to xenograft on histologic scoring in the eighth week.But no significant difference was demonstrated between two groups in twelfth week after operation on radiographic and histologic shudies.

Conclusion:Xenograft bone appears a promising alternative to repair bone defect.

引用本文，请按以下格式著录参考文献：

中文格式:	刘玉增,李琪文,王继芳.冻干同种异体骨与冻干异种骨移植治疗骨缺损的比较实验研究[J].中国骨伤,2005,18(5):282~284
英文格式:	LIU Yu-zeng,LI Qi-wen,WANG Ji-fang.Experimental comparison of freeze-drying allograft bone with freeze-drying xenograft bone for the repair of segmental bone defect[J].zhongguo gu shang / China J Orthop Trauma ,2005,18(5):282~284

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