| 植入型复方丹参缓释剂对骨折愈合影响的实验研究 |
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Received:April 05, 2004
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| 作者 | Author | 单位 | Unit | E-Mail |
| 王俊国 |
WANG Jun-guo |
青岛市海慈医疗集团海慈医院骨科,山东青岛266042 |
Department of Orthopaedic,Haici Hospital of Qingdao,Shandong Qingdao,266042,China |
w angig76@ yahoo. |
| 曹斌 |
CAO Bin |
青岛市海慈医疗集团海慈医院骨科,山东青岛266042 |
Department of Orthopaedic,Haici Hospital of Qingdao,Shandong Qingdao,266042,China |
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| 唐胜建 |
TANG Sheng-jian |
潍坊医学院整形外科医院 |
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| 刘永辉 |
LIU Yong-hui |
青岛市海慈医疗集团海慈医院骨科,山东青岛266042 |
Department of Orthopaedic,Haici Hospital of Qingdao,Shandong Qingdao,266042,China |
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| 张守平 |
ZHANG Shou-ping |
青岛市海慈医疗集团海慈医院骨科,山东青岛266042 |
Department of Orthopaedic,Haici Hospital of Qingdao,Shandong Qingdao,266042,China |
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| 期刊信息：《中国骨伤》2005年18卷，第1期，第28-31页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的:观察丹参缓释剂植入骨折局部对骨折愈合的影响。
方法:42只新西兰健康白兔随机分为两组,均于右前肢桡骨中段制成3mm骨缺损的骨折模型,同时实验组放置丹参缓释剂60mg,对照组放置等量赋形剂。分别于术后第2、4、5、6周取右桡骨行X线片及组织学检查;第2、4、6周行电镜及骨密度检查;第5、6周进行生物力学测试。
结果:X线片显示实验组较对照组骨折愈合提前。组织学观察实验组纤维性骨痂、软骨性骨痂、骨小梁之间过渡加快,毛细血管增生明显。电镜检查实验组示骨折修复细胞形态学变化均有利于修复骨折。术后第2、4、6周时骨密度值实验组均较对照组高,其中第4周时两者差异具有显著性(P<005)。术后第5、6周实验组抗折力均较对照组高(P<005)。
结论:在骨折局部使用丹参缓释剂对骨折愈合具有一定的促进作用。 |
| [关键词]:丹参 骨折愈合 组织学 骨密度 |
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| Experimental research on the effect of implantation of controlled-releasing Radix salvia miltiorrhiza on radial fracture healing |
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Abstract:
Objective:To evaluate the effects of implantation of controlled-releasing Radix salvia miltiorrhiza on fracture healing.
Methods:Standard fracture models were established in the middle of right radii of New Zealand healthy white rabbits.42 rabbits were divided randomly into experiment group and control group,60 mg controlled-releasing Radix salvia miltiorrhiza were implanted into the fracture site in experiment group and 60 mg excipient in control group.Radiography,histological and electron-microscopic examination were done respectively.BMD was detected at the 2,4,6 th week after the operation.Biomechanics test was employed at the 5,6 th week after the operation.
Results::X-ray films showed fracture healing was earlier in the experiment group than that in the control group.Histological examination showed in the experiment group the transformation of fibrous callus,cartilaginous callus and trabecular bone were faster than that in the control group.The capillary hyperplasia was obvious.The electron-microscopic examination showed all morphological changes facilitated to fracture healing.BMD at fracture site were higher in the experiment group than that in the control group;moreover,the difference of BMD at the 4 th week had statistical significance（P<0.05）.The figures of anti-fracture strength in the experiment group were greater at the 5,6 th week,and the difference had statistical significance（P<0.05）.
Conclusion:Implantation of controlled-releasing Radix salvia miltiorrhiza can accelerate fracture healing. |
| KEYWORDS:Radix salvia miltiorrhiza Fractures healing Histology Bone density |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 王俊国,曹斌,唐胜建,刘永辉,张守平.植入型复方丹参缓释剂对骨折愈合影响的实验研究[J].中国骨伤,2005,18(1):28~31 |
| 英文格式: | WANG Jun-guo,CAO Bin,TANG Sheng-jian,LIU Yong-hui,ZHANG Shou-ping.Experimental research on the effect of implantation of controlled-releasing Radix salvia miltiorrhiza on radial fracture healing[J].zhongguo gu shang / China J Orthop Trauma ,2005,18(1):28~31 |
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