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骨生注射液对实验性骨性关节炎家兔血浆SOD和MDA的影响

Hits: 2320 Download times: 1366 Received:January 13, 2003

作者	Author	单位	Unit	E-Mail
江中潮	JIANG Zhong-chao	成都中医药大学附属医院骨科, 四川成都 610072	Department of Orthopaedics, the Affiliated Hospital of Chengdu University of TCM	PJSS@sina100.com
何洪阳	HE Hong-yang	成都中医药大学附属医院骨科, 四川成都 610072	Department of Orthopaedics, the Affiliated Hospital of Chengdu University of TCM
刘罡	LIU Gang	成都军区陆军第42医院骨科
邓友章	DENG You-zhang	成都中医药大学骨科
黄勇	HUANG Yong	成都中医药大学附属医院骨科, 四川成都 610072	Department of Orthopaedics, the Affiliated Hospital of Chengdu University of TCM
刘毅	LIU Yi	成都中医药大学附属医院骨科, 四川成都 610072	Department of Orthopaedics, the Affiliated Hospital of Chengdu University of TCM
肖裕华	XIAO Yu-hua	成都中医药大学骨科

期刊信息：《中国骨伤》2004年17卷，第10期，第593-595页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

基金项目:四川省教委资助课题(509)

目的:探讨骨生注射液对骨性关节炎的治疗作用。

方法:用日本大耳白兔造成骨性关节炎模型并分组治疗,观察各组动物的组织学变化并将血浆超氧化物歧化酶(SOD)、丙二醛(MDA)作为观测指标。

结果:光镜下显示模型组胫骨侧软骨坏死脱落,骨质裸露,SOD下降,MDA上升。经骨生注射液治疗,可见蓝绿色胶原保留达1／2以上,血中SOD明显升高,MDA下降。

结论:骨生注射液能有效对抗关节炎软骨退变,增强机体清除自由基的能力,治疗骨性关节炎。

[关键词]:骨性关节炎超氧化物歧化酶丙二醛

Experimental research of the effect of "Gusheng injection" on plasm SOD and MDA of osteoarthritic rabbies

Abstract:

Objective: To explore the effect of "Gusheng injection" (GSI) on the treatment of os-teoarthritic (OA).

Methods:OA experimental models were made in Japanese white rabbits. The rabbits were devided into different groups for different treatment. Histological changes of superoxide dismutase(SOD) and MDA were observed.

Results: In the model group, necrosis and exfoliation of tibial cartilage and exposed sub-chondral bone were observed with light microscope. SOD level decreased and MDA level increased in plasm. However,in the GSI group,more than 1/2 collagen were kept. SOD level obviously increased and MDA level decreased in plasm.

Conclusion:GSI can prevent degeneration of articular cartilage, improve the ability to clear free radical. There is reasonable effect for the treatment of OA.

KEYWORDS:Osteoarthritis SOD MDA

引用本文，请按以下格式著录参考文献：

中文格式:	江中潮,何洪阳,刘罡,邓友章,黄勇,刘毅,肖裕华.骨生注射液对实验性骨性关节炎家兔血浆SOD和MDA的影响[J].中国骨伤,2004,17(10):593~595
英文格式:	JIANG Zhong-chao,HE Hong-yang,LIU Gang,DENG You-zhang,HUANG Yong,LIU Yi,XIAO Yu-hua.Experimental research of the effect of "Gusheng injection" on plasm SOD and MDA of osteoarthritic rabbies[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(10):593~595

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