| α-SMA在先天性肌性斜颈中的表达及意义 |
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Received:December 05, 2003
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| 作者 | Author | 单位 | Unit | E-Mail |
| 陈根强 |
CHEN Gen-qiang |
浙江大学医学院附属第二医院,浙江杭州310009 |
Department of Orthopaedics and Pathological Division,The Second Affiliated Hospital,The Medical Collego of Zhejian University |
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| 潘志军 |
PAN Zhi-jun |
浙江大学医学院附属第二医院,浙江杭州310009 |
Department of Orthopaedics and Pathological Division,The Second Affiliated Hospital,The Medical Collego of Zhejian University |
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| 周燕 |
ZHOU Yan |
浙江大学医学院附属第二医院,浙江杭州310009 |
Department of Orthopaedics and Pathological Division,The Second Affiliated Hospital,The Medical Collego of Zhejian University |
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| 陈丽荣 |
CHEN Li-rong |
浙江大学医学院附属第二医院,浙江杭州310009 |
Department of Orthopaedics and Pathological Division,The Second Affiliated Hospital,The Medical Collego of Zhejian University |
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| 期刊信息：《中国骨伤》2004年17卷，第8期，第452-454页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的:研究α平滑肌肌动蛋白(alphasmoothmuscleactin,αSMA)在先天性肌性斜颈(congenitalmusculartorticollis,CMT)中的表达及意义。
方法:利用免疫组化辅以计算机图象定量分析技术,对21例先天性肌性斜颈及10例正常肌肉腱性组织标本αSMA的表达进行观察和检测。
结果:αSMA在对照组中未见明显表达,3例先天性肌性斜颈标本αSMA染色阴性,18例病变标本中αSMA染色阳性,病变组与对照组两者差异有非常显著性意义(P<0.001);αSMA在肌性斜颈中表达强度与年龄有关,6岁以上组表达明显减弱,与6岁以下组(包括6岁)比较差异有显著性意义(P<0.001)。
结论:①肌纤维母细胞是先天性肌性斜颈发病关键病理因素。②先天性肌性斜颈中肌纤维母细胞的表达在6岁以上组明显减弱,这给临床治疗提供新思路。 |
| [关键词]:先天性肌性斜颈 肌动蛋白 肌纤维母细胞 免疫组织化学 |
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| Expression and significance of alpha-smooth muscle actin in congenital muscular torticollis |
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Abstract:
Objective:To study the expression and distribution of alpha-smooth muscle actin(α-SMA)in congenital muscle torticollis and discuss its clinical significance and relationship with congenital muscular torticollis.
Methods:Twenty specimens from congenital muscular torticollis were collected.The control specimens were collected from normal tendon samples.Expression of α-SMA was detected using immunohistochemistry and computer image evaluation in twenty-one cases and ten normal tendon smaples.
Results:There was no significant expression of α-SMA in control group except for the positive reaction in the smooth muscle cells of the small vascular walls.Eighteen specimens of congenital muscular torticollis were positive for α-SMA.Three specimens of congenital muscle torticollis were negative for α-SMA.α-SMA was expressed in the diseased group,which carried a striking difference from its constrasting group(P<0.001);In the congenital muscle torticollis group,the expression of α-SMA of those aged over six-years old was also weakened obviously,whose difference from the those aged less than six-years old(including six)was alse with significant different(P<0.001).
Conclusion:① Myofibroblasts appear to be one of the most important factors in the pathogenesis of congenital muscular torticollis.② The expression of myofibroblast in congenital muscular torticollis,aged over six group weakened obviously,which gives fresh thought to cure of these diseases. |
| KEYWORDS:Congenital muscular torticollis Actins Myofibroblast Immunohistochemical |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陈根强,潘志军,周燕,陈丽荣.α-SMA在先天性肌性斜颈中的表达及意义[J].中国骨伤,2004,17(8):452~454 |
| 英文格式: | CHEN Gen-qiang,PAN Zhi-jun,ZHOU Yan,CHEN Li-rong.Expression and significance of alpha-smooth muscle actin in congenital muscular torticollis[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(8):452~454 |
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